alectinib resistant ALK mutants [plasma membrane]

Stable Identifier
R-HSA-9700560
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
25228534 Two novel ALK mutations mediate acquired resistance to the next-generation ALK inhibitor alectinib

Katayama, R, Friboulet, L, Koike, S, Lockerman, EL, Khan, TM, Gainor, JF, Iafrate, AJ, Takeuchi, K, Taiji, M, Okuno, Y, Fujita, N, Engelman, JA, Shaw, AT

Clin Cancer Res 2014
24509625 Activating mutations in ALK kinase domain confer resistance to structurally unrelated ALK inhibitors in NPM-ALK-positive anaplastic large-cell lymphoma

Zdzalik, D, Dymek, B, Grygielewicz, P, Gunerka, P, Bujak, A, Lamparska-Przybysz, M, Wieczorek, M, Dzwonek, K

J Cancer Res Clin Oncol 2014
31374369 Rapid Acquisition of Alectinib Resistance in ALK-Positive Lung Cancer With High Tumor Mutation Burden

Makimoto, G, Ohashi, K, Tomida, S, Nishii, K, Matsubara, T, Kayatani, H, Higo, H, Ninomiya, K, Sato, A, Watanabe, H, Kano, H, Ninomiya, T, Kubo, T, Rai, K, Ichihara, E, Hotta, K, Tabata, M, Toyooka, S, Takata, M, Maeda, Y, Kiura, K

J Thorac Oncol 2019
27432227 Molecular Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in ALK-Rearranged Lung Cancer

Gainor, JF, Dardaei, L, Yoda, S, Friboulet, L, Leshchiner, I, Katayama, R, Dagogo-Jack, I, Gadgeel, S, Schultz, K, Singh, M, Chin, E, Parks, M, Lee, D, DiCecca, RH, Lockerman, E, Huynh, T, Logan, J, Ritterhouse, LL, Le, LP, Muniappan, A, Digumarthy, S, Channick, C, Keyes, C, Getz, G, Dias-Santagata, D, Heist, RS, Lennerz, J, Sequist, LV, Benes, CH, Iafrate, AJ, Mino-Kenudson, M, Engelman, JA, Shaw, AT

Cancer Discov 2016
26464158 ALK F1174V mutation confers sensitivity while ALK I1171 mutation confers resistance to alectinib. The importance of serial biopsy post progression

Ou, SH, Milliken, JC, Azada, MC, Miller, VA, Ali, SM, Klempner, SJ

Lung Cancer 2016
25393796 Identification of a novel HIP1-ALK fusion variant in Non-Small-Cell Lung Cancer (NSCLC) and discovery of ALK I1171 (I1171N/S) mutations in two ALK-rearranged NSCLC patients with resistance to Alectinib

Ou, SH, Klempner, SJ, Greenbowe, JR, Azada, M, Schrock, AB, Ali, SM, Ross, JS, Stephens, PJ, Miller, VA

J Thorac Oncol 2014
27130468 Anaplastic Lymphoma Kinase (ALK) Kinase Domain Mutation Following ALK Inhibitor(s) Failure in Advanced ALK Positive Non-Small-Cell Lung Cancer: Analysis and Literature Review

Lin, YT, Yu, CJ, Yang, JC, Shih, JY

Clin Lung Cancer 2016
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Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
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