Reactome | alectinib sensitve ALK mutants [plasma membrane]

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alectinib sensitve ALK mutants [plasma membrane] Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9700562] Rothfels, Karen, 2020-09-16
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9700555
disease	[Disease:1500689] cancer
displayName	alectinib sensitve ALK mutants [plasma membrane]
hasMember	[Complex:R-HSA-9699978] ALK F1174I dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9699987] ALK F1174L dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9700005] ALK F1174V dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9699985] EML4(1-223)-ALK(1059-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9699976] EML4(1-223)insKMSTREKNSQV -ALK(1059-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9700022] EML4(1-486)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9712019] HIP1(1-1019)-ALK(1058-1620) dimer [cytosol] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:9700317] ALK F1174V mutation confers sensitivity while ALK I1171 mutation confers resistance to alectinib. The importance of serial biopsy post progression [LiteratureReference:9700360] Structural insight into selectivity and resistance profiles of ROS1 tyrosine kinase inhibitors [LiteratureReference:9711845] Identification of a novel HIP1-ALK fusion variant in Non-Small-Cell Lung Cancer (NSCLC) and discovery of ALK I1171 (I1171N/S) mutations in two ALK-rearranged NSCLC patients with resistance to Alectinib [LiteratureReference:9700357] Treatment Efficacy and Resistance Mechanisms Using the Second-Generation ALK Inhibitor AP26113 in Human NPM-ALK-Positive Anaplastic Large Cell Lymphoma
maxDepth	3
memberOf	[DefinedSet:R-HSA-9699981] type I TKI sensitive ALK mutants [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9716606] Rothfels, Karen, 2021-02-22
name	alectinib sensitve ALK mutants
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-9700555

Referrals

(hasMember)

[DefinedSet:R-HSA-9699981] type I TKI sensitive ALK mutants [plasma membrane]

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