Reactome | PTPRZ dephosphorylates ligand-bound ALK dimers

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PTPRZ dephosphorylates ligand-bound ALK dimers Show undefined attributes

authored	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
catalystActivity	[CatalystActivity:9700110] protein tyrosine phosphatase activity of C4S-PTPRZ1 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9700201] Rothfels, Karen, 2020-09-14
dbId	9700200
displayName	PTPRZ dephosphorylates ligand-bound ALK dimers
edited	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
eventOf	[Pathway:R-HSA-9851151] MDK and PTN in ALK signaling - Homo sapiens
input	[DefinedSet:R-HSA-9700013] (PTN,MDK):p-7Y ALK dimer [plasma membrane] 6 × [SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9699636] Anaplastic lymphoma kinase is activated through the pleiotrophin/receptor protein-tyrosine phosphatase beta/zeta signaling pathway: an alternative mechanism of receptor tyrosine kinase activation [LiteratureReference:9699755] Protein tyrosine phosphatase receptor type Z is inactivated by ligand-induced oligomerization [LiteratureReference:9699615] A receptor-like protein-tyrosine phosphatase PTPzeta/RPTPbeta binds a heparin-binding growth factor midkine. Involvement of arginine 78 of midkine in the high affinity binding to PTPzeta [LiteratureReference:9699772] Role of Chondroitin Sulfate (CS) Modification in the Regulation of Protein-tyrosine Phosphatase Receptor Type Z (PTPRZ) Activity: PLEIOTROPHIN-PTPRZ-A SIGNALING IS INVOLVED IN OLIGODENDROCYTE DIFFERENTIATION [LiteratureReference:9667892] Anaplastic lymphoma kinase: "Ligand Independent Activation" mediated by the PTN/RPTP?/? signaling pathway
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	PTPRZ dephosphorylates ligand-bound ALK dimers
orthologousEvent	[Reaction:R-GGA-9700200] PTPRZ dephosphorylates ligand-bound ALK dimers - Gallus gallus [Reaction:R-SSC-9700200] PTPRZ dephosphorylates ligand-bound ALK dimers - Sus scrofa [Reaction:R-BTA-9700200] PTPRZ dephosphorylates ligand-bound ALK dimers - Bos taurus [Reaction:R-CFA-9700200] PTPRZ dephosphorylates ligand-bound ALK dimers - Canis familiaris [Reaction:R-RNO-9700200] PTPRZ dephosphorylates ligand-bound ALK dimers - Rattus norvegicus [Reaction:R-MMU-9700200] PTPRZ dephosphorylates ligand-bound ALK dimers - Mus musculus
output	[DefinedSet:R-HSA-9700086] (PTN,MDK):ALK dimer [plasma membrane] 6 × [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-HSA-201521] ALK autophosphorylation - Homo sapiens
regulatedBy	[NegativeRegulation:9700199] Negative regulation by '(PTN,MDK):PTPRZ oligomers [plasma membrane]'
releaseDate	2021-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9700200
summation	[Summation:9700127] ALK is dephosphorylated by PTPRZ leading to loss of activity...

Referrals

(hasEvent)

[Pathway:R-HSA-9851151] MDK and PTN in ALK signaling