Reactome | midostaurin-resistant FLT3 mutants [plasma membrane]

Schema > DefinedSet > Entries

midostaurin-resistant FLT3 mutants [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
consumedByEvent	[FailedReaction:R-HSA-9702601] midostaurin-resistant FLT3 mutants don't bind midostaurin - Homo sapiens
created	[InstanceEdit:9699524] Rothfels, Karen, 2020-09-14
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9699536
disease	[Disease:1500689] cancer
displayName	midostaurin-resistant FLT3 mutants [plasma membrane]
hasMember	[Complex:R-HSA-9691983] FLT3 Y591_V592insVDFREYEYDH dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9692035] FLT3 S451F dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9699481] FLT3 A627P dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9702897] FLT3 N676D dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9695766] FLT3 N676K dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9695764] FLT3 N676S dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9695762] FLT3 F691L dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9702905] FLT3 F691I dimer [plasma membrane] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:9699239] Clinical resistance to the kinase inhibitor PKC412 in acute myeloid leukemia by mutation of Asn-676 in the FLT3 tyrosine kinase domain [LiteratureReference:9691821] Identification of a novel type of ITD mutations located in nonjuxtamembrane domains of the FLT3 tyrosine kinase receptor [LiteratureReference:9699355] Prediction of resistance to small molecule FLT3 inhibitors: implications for molecularly targeted therapy of acute leukemia [LiteratureReference:9699304] FMS-like tyrosine kinase 3-internal tandem duplication tyrosine kinase inhibitors display a nonoverlapping profile of resistance mutations in vitro [LiteratureReference:9699384] The secondary FLT3-ITD F691L mutation induces resistance to AC220 in FLT3-ITD+ AML but retains in vitro sensitivity to PKC412 and Sunitinib [LiteratureReference:9699271] Emergence of polyclonal FLT3 tyrosine kinase domain mutations during sequential therapy with sorafenib and sunitinib in FLT3-ITD-positive acute myeloid leukemia [LiteratureReference:9691838] Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles [LiteratureReference:9702890] The effects of lestaurtinib (CEP701) and PKC412 on primary AML blasts: the induction of cytotoxicity varies with dependence on FLT3 signaling in both FLT3-mutated and wild-type cases
maxDepth	3
modified	[InstanceEdit:9703076] Rothfels, Karen, 2020-10-05
name	midostaurin-resistant FLT3 mutants
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-9699536

Referrals

(input)	[FailedReaction:R-HSA-9702601] midostaurin-resistant FLT3 mutants don't bind midostaurin
(diseaseEntity)	[EntityFunctionalStatus:9702602] loss_of_function of midostaurin-resistant FLT3 mutants [plasma membrane]

© 2026 Reactome

Cite Us!