midostaurin-resistant FLT3 mutants [plasma membrane]

Stable Identifier
Set [DefinedSet]
Homo sapiens
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
15374944 Prediction of resistance to small molecule FLT3 inhibitors: implications for molecularly targeted therapy of acute leukemia

Marynen, P, Griffin, JD, Furet, P, Gilliland, DG, Fabbro, D, Mentens, N, Clark, JJ, Cools, J

Cancer Res. 2004
16868253 The effects of lestaurtinib (CEP701) and PKC412 on primary AML blasts: the induction of cytotoxicity varies with dependence on FLT3 signaling in both FLT3-mutated and wild-type cases

Gilkes, AF, Mills, KI, Austin, SJ, Burnett, AK, Knapper, S, Walsh, V

Blood 2006
18483393 Identification of a novel type of ITD mutations located in nonjuxtamembrane domains of the FLT3 tyrosine kinase receptor

Grundler, R, Schnittger, S, Haferlach, T, Duyster, J, Breitenbuecher, F, Huber, C, Brecht, A, Markova, B, Fischer, T, Carius, B

Blood 2009
18068628 Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles

Griffin, JD, Golub, TR, Gilliland, DG, Heinrich, MC, Ebert, BL, Stone, RM, Jiang, J, Schittenhelm, MM, Berger, R, Lee, BH, Deininger, MW, Teckie, S, Döhner, K, Loriaux, M, Fröhling, S, Bernard, OA, Scholl, C, Boggon, TJ, Levine, RL, Döhner, H, Druker, BJ

Cancer Cell 2007
23392356 The secondary FLT3-ITD F691L mutation induces resistance to AC220 in FLT3-ITD+ AML but retains in vitro sensitivity to PKC412 and Sunitinib

Yu, C, Albers, C, Verbeek, M, Duyster, J, Leischner, H, Illert, AL, von Bubnoff, N, Peschel, C

Leukemia 2013
19318574 FMS-like tyrosine kinase 3-internal tandem duplication tyrosine kinase inhibitors display a nonoverlapping profile of resistance mutations in vitro

Duyster, J, Sänger, J, Aberg, E, Engh, RA, Peschel, C, von Bubnoff, N

Cancer Res. 2009
23969938 Emergence of polyclonal FLT3 tyrosine kinase domain mutations during sequential therapy with sorafenib and sunitinib in FLT3-ITD-positive acute myeloid leukemia

Mullighan, CG, Baker, SD, Rubnitz, JE, Zimmerman, EI, Orwick, S, Inaba, H, Neale, GA, Zatechka, DS, Buaboonnam, J, Enemark, EJ, Shurtleff, S, Wang, YD, Olsen, SR

Clin. Cancer Res. 2013
16150941 Clinical resistance to the kinase inhibitor PKC412 in acute myeloid leukemia by mutation of Asn-676 in the FLT3 tyrosine kinase domain

Heidel, F, Serve, H, Solem, FK, Schiller, GJ, Breitenbuecher, F, Giles, F, Nimer, S, Wang, Y, Feldman, E, Kindler, T, Stone, RM, Thiede, MH, Huber, C, Brandts, C, Lipka, DB, Roesel, J, Kasper, S, Ehninger, G, Cohen, PS, Fischer, T

Blood 2006
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
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