Reactome | lestaurtinib-sensitive FLT3 mutants [plasma membrane]

Schema > DefinedSet > Entries

lestaurtinib-sensitive FLT3 mutants [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9699524] Rothfels, Karen, 2020-09-14
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9699520
disease	[Disease:1500689] cancer
displayName	lestaurtinib-sensitive FLT3 mutants [plasma membrane]
hasMember	[Complex:R-HSA-9699483] FLT3 E596_Y597insRTDFRE dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9691983] FLT3 Y591_V592insVDFREYEYDH dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9696081] FLT3 E598_Y599insFDFREYE dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9699476] FLT3 L610_E611insLKWEFPRENL dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9699489] FLT3 E611_F612insGDNEYFYVDFREYEYDLKWEFPRENLE dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9699494] FLT3 F621L dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9695762] FLT3 F691L dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9682330] FLT3 D835A dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9682338] FLT3 D835G dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9682344] FLT3 D835N dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9682356] FLT3 D835Y dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9699491] FLT3 Y842C dimer [plasma membrane] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:9699345] Mutations of FLT3/ITD confer resistance to multiple tyrosine kinase inhibitors [LiteratureReference:9702890] The effects of lestaurtinib (CEP701) and PKC412 on primary AML blasts: the induction of cytotoxicity varies with dependence on FLT3 signaling in both FLT3-mutated and wild-type cases [LiteratureReference:9697855] Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival [LiteratureReference:9702954] FLT3 activating mutations display differential sensitivity to multiple tyrosine kinase inhibitors
maxDepth	3
memberOf	[DefinedSet:R-HSA-9702522] type I TKI sensitive FLT3 mutants [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9703028] Rothfels, Karen, 2020-10-03
name	lestaurtinib-sensitive FLT3 mutants
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-9699520

Referrals

(hasMember)

[DefinedSet:R-HSA-9702522] type I TKI sensitive FLT3 mutants [plasma membrane]

© 2026 Reactome

Cite Us!