lestaurtinib-sensitive FLT3 mutants [plasma membrane]

Stable Identifier
R-HSA-9699520
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
28077790 FLT3 activating mutations display differential sensitivity to multiple tyrosine kinase inhibitors

Nguyen, B, Williams, AB, Young, DJ, Ma, H, Li, L, Levis, M, Brown, P, Small, D

Oncotarget 2017
16868253 The effects of lestaurtinib (CEP701) and PKC412 on primary AML blasts: the induction of cytotoxicity varies with dependence on FLT3 signaling in both FLT3-mutated and wild-type cases

Knapper, S, Mills, KI, Gilkes, AF, Austin, SJ, Walsh, V, Burnett, AK

Blood 2006
15498859 Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival

Kim, KT, Baird, K, Ahn, JY, Meltzer, P, Lilly, M, Levis, M, Small, D

Blood 2005
22858906 Mutations of FLT3/ITD confer resistance to multiple tyrosine kinase inhibitors

Williams, AB, Nguyen, B, Li, L, Brown, P, Levis, M, Leahy, D, Small, D

Leukemia 2013
Participants
members
Participates
as a member of
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
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