FLT3 mutant dimers:GRB2 bind SOS1

Stable Identifier
R-HSA-9695845
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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FLT3 mutant dimers:GRB2 bind SOS1
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SOS1 is presumed to be recruited to FLT3 receptors through interaction with GRB2, as is the case for the wild-type receptor (reviewed in Kazi and Ronnstrand, 2019). SOS is a nucleotide exchange factor for RAS and activates signaling through the RAS-RAF-MAPK pathway downstream of oncogenic FLT3 mutants (Zhang et al, 1999; Mizuki et al, 2000; Hayakawa et al, 2000; Voisset et al, 2010; Arora et al, 2011; reviewed in Kazi and Ronnstrand, 2019).

Literature References
PubMed ID Title Journal Year
11090077 Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways

Mizuki, M, Fenski, R, Halfter, H, Matsumura, I, Schmidt, R, Müller, C, Grüning, W, Kratz-Albers, K, Serve, S, Steur, C, Büchner, T, Kienast, J, Kanakura, Y, Berdel, WE, Serve, H

Blood 2000
31066629 FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications

Kazi, JU, Rönnstrand, L

Physiol. Rev. 2019
10698507 Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines

Hayakawa, F, Towatari, M, Kiyoi, H, Tanimoto, M, Kitamura, T, Saito, H, Naoe, T

Oncogene 2000
21262971 Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling

Arora, D, Stopp, S, Böhmer, SA, Schons, J, Godfrey, R, Masson, K, Razumovskaya, E, Rönnstrand, L, Tänzer, S, Bauer, R, Böhmer, FD, Müller, JP

J. Biol. Chem. 2011
10080542 Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells

Zhang, S, Mantel, C, Broxmeyer, HE

J. Leukoc. Biol. 1999
Participants
Input
Output
Participant Of
hasEvent
Normal reaction
Active FLT3:GRB2 binds SOS1 (Homo sapiens)
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2020-11-06)
Reviewed
Kazi, JU  (2020-11-06)
Created
Rothfels, K  (2020-07-15)
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