Reactome | nsp3 cleaves nsp1-4

Schema > Reaction > Entries

nsp3 cleaves nsp1-4 Show undefined attributes

authored	[InstanceEdit:9683039] Stephan, Ralf, 2020-04-14
catalystActivity	[CatalystActivity:9684258] cysteine-type endopeptidase activity of N-glycan nsp3 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9684359] Stephan, Ralf, 2020-04-21
crossReference	[DatabaseIdentifier:12020764] Mondo:0005091
dbId	9684321
disease	[Disease:9678120] severe acute respiratory syndrome
displayName	nsp3 cleaves nsp1-4
edited	[InstanceEdit:9689806] D'Eustachio, Peter, 2020-05-21
eventOf	[Pathway:R-HSA-9684325] Maturation of replicase proteins - Homo sapiens
followingEvent	[Reaction:R-HSA-9731009] SARS-CoV-1 nsp3 binds to IRF3 - Homo sapiens [BlackBoxEvent:R-HSA-9684261] nsp4 is glycosylated - Homo sapiens
input	3 × [SimpleEntity:R-ALL-29356] H2O [cytosol] [DefinedSet:R-COV-9684866] nsp1-4 [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9682792] Mechanisms and enzymes involved in SARS coronavirus genome expression [LiteratureReference:9684306] Identification of severe acute respiratory syndrome coronavirus replicase products and characterization of papain-like protease activity
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	nsp3 cleaves nsp1-4
output	[DefinedSet:R-COV-9682210] nsp1 [cytosol] [DefinedSet:R-COV-9682222] nsp2 [cytosol] [DefinedSet:R-COV-9684877] nsp3 [cytosol] [DefinedSet:R-COV-9684876] nsp4 [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9684290] nsp3 is glycosylated - Homo sapiens
relatedSpecies	[Species:9678119] Human SARS coronavirus
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9690206] Acencio, Marcio Luis, Mazein, Alexander, 2020-05-27
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9684321
summation	[Summation:9684324] Glycosylated nsp3 (papain-like protease) cleaves the N-proxi...

Referrals

(precedingEvent)	[Reaction:R-HSA-9731009] SARS-CoV-1 nsp3 binds to IRF3 [BlackBoxEvent:R-HSA-9684261] nsp4 is glycosylated
(hasEvent)	[Pathway:R-HSA-9684325] Maturation of replicase proteins

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