nsp3 cleaves nsp1-4

Stable Identifier
R-HSA-9684321
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
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Glycosylated nsp3 (papain-like protease) cleaves the N-proximal polyprotein regions at three sites (Thiel et al, 2003; Harcourt et al, 2004)

Literature References
PubMed ID Title Journal Year
12917450 Mechanisms and enzymes involved in SARS coronavirus genome expression

Rabenau, H, Schelle, B, Hertzig, T, Ivanov, KA, Gorbalenya, AE, Putics, Á, Bayer, S, Ziebuhr, J, Thiel, V, Doerr, HW, Weißbrich, B, Snijder, EJ

J. Gen. Virol. 2003
15564471 Identification of severe acute respiratory syndrome coronavirus replicase products and characterization of papain-like protease activity

Severson, KM, Baker, SC, Jukneliene, D, Rota, PA, Harcourt, BH, Smith, CM, Bechill, J, Kanjanahaluethai, A

J. Virol. 2004
Participants
Participates
Catalyst Activity

cysteine-type endopeptidase activity of N-glycan nsp3 [endoplasmic reticulum membrane]

Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Reviewed
Created
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