Reactome | GSK3 phosphorylates Nucleoprotein

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GSK3 phosphorylates Nucleoprotein Show undefined attributes

authored	[InstanceEdit:9683645] Stephan, Ralf, 2020-04-08
catalystActivity	[CatalystActivity:5661486] protein serine/threonine kinase activity of GSK3 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9683729] Stephan, Ralf, 2020-04-17
crossReference	[DatabaseIdentifier:12020764] Mondo:0005091
dbId	9683664
deleted	[Deleted:9728920] Deletion of instance: 9681627
disease	[Disease:9678120] severe acute respiratory syndrome
displayName	GSK3 phosphorylates Nucleoprotein
edited	[InstanceEdit:9689806] D'Eustachio, Peter, 2020-05-21
eventOf	[Pathway:R-HSA-9683610] Maturation of nucleoprotein - Homo sapiens
followingEvent	[Reaction:R-HSA-9686061] Nucleoprotein is ADP-ribosylated - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-COV-9683625] N [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9682961] The severe acute respiratory syndrome coronavirus nucleocapsid protein is phosphorylated and localizes in the cytoplasm by 14-3-3-mediated translocation [LiteratureReference:9680322] Glycogen synthase kinase-3 regulates the phosphorylation of severe acute respiratory syndrome coronavirus nucleocapsid protein and viral replication
maxDepth	1
modified	[InstanceEdit:9937650] Stephan, Ralf, 2025-02-05
name	GSK3 phosphorylates Nucleoprotein Phosphorylation of nucleoprotein
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [EntityWithAccessionedSequence:R-COV-9683754] p-S177-N [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9683735] mRNA9 is translated to Nucleoprotein - Homo sapiens
regulatedBy	[NegativeRegulation:9687655] Negative regulation by 'GSK3B:GSKi [cytosol]'
relatedSpecies	[Species:9678119] Human SARS coronavirus
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9690206] Acencio, Marcio Luis, Mazein, Alexander, 2020-05-27
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9683664
summation	[Summation:9683028] The majority of nucleocapsid protein (N) is serine-phosphory...
updateTrackers	[UpdateTracker:9776116] Update Tracker - [Reaction:9683664] GSK3 phosphorylates Nucleoprotein - v77:[addLiteratureReference, add_removeCatalystActivity, modifyText]

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(updatedInstance)	[UpdateTracker:9776116] Update Tracker - [Reaction:9683664] GSK3 phosphorylates Nucleoprotein - v77:[addLiteratureReference, add_removeCatalystActivity, modifyText]
(replacementInstances)	[Deleted:9728920] Deletion of instance: 9681627
(hasEvent)	[Pathway:R-HSA-9683610] Maturation of nucleoprotein
(precedingEvent)	[Reaction:R-HSA-9686061] Nucleoprotein is ADP-ribosylated

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