GSK3 phosphorylates Nucleoprotein

Stable Identifier
R-HSA-9683664
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
cytosol
Synonyms
Phosphorylation of nucleoprotein
ReviewStatus
5/5
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GSK3 phosphorylates Nucleoprotein
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The majority of nucleocapsid protein (N) is serine-phosphorylated in the cytosol and, possibly, in the nucleus where it gets immediately transported to the cytosol. Phosphorylation is catalyzed by glycogen synthase kinase 3 (GSK3A and GSK3B) and several other host cell kinases (Surjit et al, 2005; Wu et al. 2009). GSK3-mediated phosphorylation of the N protein is needed for efficient replication of viral genomic RNA (Wu et al. 2009).
Literature References
PubMed ID Title Journal Year
16103198 The severe acute respiratory syndrome coronavirus nucleocapsid protein is phosphorylated and localizes in the cytoplasm by 14-3-3-mediated translocation

Mishra, RN, Kumar, R, Reddy, MK, Chow, VT, Surjit, M, Lal, SK

J. Virol. 2005
19106108 Glycogen synthase kinase-3 regulates the phosphorylation of severe acute respiratory syndrome coronavirus nucleocapsid protein and viral replication

Wu, CH, Tsay, YG, Chen, PJ, Kao, CL, Kuo, TJ, Chen, DS, Chen, YS, Wang, SH, Shieh, YH, Yeh, SH

J. Biol. Chem. 2009
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of GSK3 [cytosol]

Physical Entity
GSK3 [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
This event is regulated
Negatively by
Regulator
GSK3B:GSKi [cytosol] (Homo sapiens)
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Stephan, R  (2020-04-08)
Created
Stephan, R  (2020-04-17)
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