Reactome | The majority of nucleocapsid protein (N) is serine-phosphory...

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created	[InstanceEdit:9683039] Stephan, Ralf, 2020-04-14
dbId	9683028
displayName	The majority of nucleocapsid protein (N) is serine-phosphory...
literatureReference	[LiteratureReference:9682961] The severe acute respiratory syndrome coronavirus nucleocapsid protein is phosphorylated and localizes in the cytoplasm by 14-3-3-mediated translocation [LiteratureReference:9680322] Glycogen synthase kinase-3 regulates the phosphorylation of severe acute respiratory syndrome coronavirus nucleocapsid protein and viral replication
modified	[InstanceEdit:9728915] Orlic-Milacic, Marija, 2021-04-23
schemaClass	Summation
text	The majority of nucleocapsid protein (N) is serine-phosphorylated in the cytosol and, possibly, in the nucleus where it gets immediately transported to the cytosol. Phosphorylation is catalyzed by glycogen synthase kinase 3 (GSK3A and GSK3B) and several other host cell kinases (Surjit et al, 2005; Wu et al. 2009). GSK3-mediated phosphorylation of the N protein is needed for efficient replication of viral genomic RNA (Wu et al. 2009).

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