Reactome | nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA

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nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA Show undefined attributes

authored	[InstanceEdit:9686443] Orlic-Milacic, Marija, 2020-04-30
catalystActivity	[CatalystActivity:9682604] 3'-5'-RNA exonuclease activity of SARS coronavirus gRNA:RTC:nascent RNA minus strand with mismatched nucleotide [double membrane vesicle viral factory outer membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:9684675] double membrane vesicle viral factory outer membrane
created	[InstanceEdit:9682611] Orlic-Milacic, Marija, 2020-04-13
crossReference	[DatabaseIdentifier:12020764] Mondo:0005091
dbId	9682603
disease	[Disease:9678120] severe acute respiratory syndrome
displayName	nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA
edited	[InstanceEdit:9687600] Orlic-Milacic, Marija, 2020-05-11
eventOf	[Pathway:R-HSA-9682706] Replication of the SARS-CoV-1 genome - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9682465] RTC completes synthesis of the minus strand genomic RNA complement - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-COV-9682566] SARS coronavirus gRNA:RTC:nascent RNA minus strand with mismatched nucleotide [double membrane vesicle viral factory outer membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9682597] Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing [LiteratureReference:9682560] Discovery of an RNA virus 3'->5' exoribonuclease that is critically involved in coronavirus RNA synthesis [LiteratureReference:9682259] One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities [LiteratureReference:9682606] Biochemical characterization of exoribonuclease encoded by SARS coronavirus [LiteratureReference:9682548] RNA 3'-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complex [LiteratureReference:9683506] Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA
output	[SimpleEntity:R-ALL-9689912] NMP [cytosol] [Complex:R-COV-9682469] SARS-CoV-1 gRNA:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9682563] nsp12 misincorporates a nucleotide in nascent RNA minus strand - Homo sapiens
relatedSpecies	[Species:9678119] Human SARS coronavirus
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9690206] Acencio, Marcio Luis, Mazein, Alexander, 2020-05-27
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9682603
summation	[Summation:9682609] nsp14 acts as 3'-5' exonuclease (Minskaia et al. 2006, Chen ...

Referrals

(hasEvent)	[Pathway:R-HSA-9682706] Replication of the SARS-CoV-1 genome
(precedingEvent)	[BlackBoxEvent:R-HSA-9682465] RTC completes synthesis of the minus strand genomic RNA complement

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