nsp7 binds nsp8

Stable Identifier
R-HSA-9680812
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
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Human SARS coronavirus nonstructural proteins nsp7 and nsp8 form a heterodimer (Kirchdoerfer and Ward 2019). The nsp7:nsp8 complex may function as a hexadecamer, composed of 8 subunits of nsp7 and 8 subunits of nsp8 (Zhai et al. 2005).

Literature References
PubMed ID Title Journal Year
16228002 Insights into SARS-CoV transcription and replication from the structure of the nsp7-nsp8 hexadecamer

Zhai, Y, Sun, F, Li, X, Pang, H, Xu, X, Bartlam, M, Rao, Z

Nat. Struct. Mol. Biol. 2005
31138817 Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors

Kirchdoerfer, RN, Ward, AB

Nat Commun 2019
Participants
Participant Of
Disease
Name Identifier Synonyms
severe acute respiratory syndrome 2945 SARS-CoV infection, SARS
Authored
Reviewed
Created
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