Reactome | p-11Y PDGFRA D842L dimer [plasma membrane]

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p-11Y PDGFRA D842L dimer [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9674334] p-11Y PDGFRA D842L [plasma membrane] - Homo sapiens [Complex:R-HSA-9674334] p-11Y PDGFRA D842L [plasma membrane] - Homo sapiens
created	[InstanceEdit:9674312] Rothfels, Karen, 2020-01-13
crossReference	[DatabaseIdentifier:12020786] Mondo:0011996
dbId	9674313
disease	[Disease:1500689] cancer [Disease:1247687] chronic myeloid leukemia
displayName	p-11Y PDGFRA D842L dimer [plasma membrane]
endCoordinate	1089
hasModifiedResidue	[ReplacedResidue:9674302] L-aspartic acid 842 replaced with L-leucine [ModifiedResidue:186764] O4'-phospho-L-tyrosine at 1018 [ModifiedResidue:186779] O4'-phospho-L-tyrosine at 572 [ModifiedResidue:186787] O4'-phospho-L-tyrosine at 574 [ModifiedResidue:186796] O4'-phospho-L-tyrosine at 720 [ModifiedResidue:186782] O4'-phospho-L-tyrosine at 731 [ModifiedResidue:186809] O4'-phospho-L-tyrosine at 742 [ModifiedResidue:186771] O4'-phospho-L-tyrosine at 754 [ModifiedResidue:186823] O4'-phospho-L-tyrosine at 762 [ModifiedResidue:186775] O4'-phospho-L-tyrosine at 768 [ModifiedResidue:186801] O4'-phospho-L-tyrosine at 988 [ModifiedResidue:389089] O4'-phospho-L-tyrosine at 849
inDisease	true
literatureReference	[LiteratureReference:9674223] FIP1L1-PDGFR? p.T674I-D842L: A Novel and Ponatinib Resistant Compound Mutation in FIP1L1-PDGFR? Positive Leukemia
maxDepth	1
name	p-11Y PDGFRA D842L dimer Alpha platelet-derived growth factor receptor PGDS_HUMAN
referenceEntity	[ReferenceGeneProduct:uniprot:P16234] UniProt:P16234 PDGFRA
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9674313
startCoordinate	24

Referrals

(hasComponent)

[Complex:R-HSA-9674334] p-11Y PDGFRA D842L [plasma membrane]

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