Reactome | Olaratumab binds PDGFRA

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Olaratumab binds PDGFRA Show undefined attributes

authored	[InstanceEdit:9677035] Rothfels, Karen, 2020-02-25
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9674016] Rothfels, Karen, 2020-01-09
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9674015
disease	[Disease:1500689] cancer
displayName	Olaratumab binds PDGFRA
edited	[InstanceEdit:9677035] Rothfels, Karen, 2020-02-25
eventOf	[Pathway:R-HSA-186797] Signaling by PDGF - Homo sapiens
input	[ProteinDrug:R-ALL-9674007] olaratumab [extracellular region] [EntityWithAccessionedSequence:R-HSA-186794] PDGFRA [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9673986] Targeting the platelet-derived growth factor receptor alpha with a neutralizing human monoclonal antibody inhibits the growth of tumor xenografts: implications as a potential therapeutic target [LiteratureReference:9673974] Stromal platelet-derived growth factor receptor ? (PDGFR?) provides a therapeutic target independent of tumor cell PDGFR? expression in lung cancer xenografts [LiteratureReference:9673955] Autocrine activation of PDGFRalpha promotes the progression of ovarian cancer [LiteratureReference:9674003] Targeting the {alpha} receptor for platelet-derived growth factor as a primary or combination therapy in a preclinical model of prostate cancer skeletal metastasis [LiteratureReference:9673963] Platelet-derived growth factor receptor-alpha: a novel therapeutic target in human hepatocellular cancer
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Olaratumab binds PDGFRA
output	[Complex:R-HSA-9674011] PDGFRA:olaratumab [plasma membrane]
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9676030] Ip, Carman K M, 2020-02-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9674015
summation	[Summation:9674013] Olaratumab is an anti-PDGFRA specific monoclonal antibody th...

Referrals

(hasEvent)

[Pathway:R-HSA-186797] Signaling by PDGF