Olaratumab binds PDGFRA

Stable Identifier
R-HSA-9674015
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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Olaratumab is an anti-PDGFRA specific monoclonal antibody that blocks the binding of PDGF-AA, PDGF-BB and PDGF-CC (Loizos et al, 2005). Olaratumab inhibits proliferation of a number of tumor cell lines and is approved for treatment of soft tissue sarcoma (Gerber et al, 2012; Loizos et al, 2005; Matei et al, 2006; Russell et al, 2010; Stock et al, 2007).

Literature References
PubMed ID Title Journal Year
22933705 Stromal platelet-derived growth factor receptor α (PDGFRα) provides a therapeutic target independent of tumor cell PDGFRα expression in lung cancer xenografts

Gerber, DE, Gupta, P, Dellinger, MT, Toombs, JE, Peyton, M, Duignan, I, Malaby, J, Bailey, T, Burns, C, Brekken, RA, Loizos, N

Mol. Cancer Ther. 2012
17604334 Platelet-derived growth factor receptor-alpha: a novel therapeutic target in human hepatocellular cancer

Stock, P, Monga, D, Tan, X, Micsenyi, A, Loizos, N, Monga, SP

Mol. Cancer Ther. 2007
15767546 Targeting the platelet-derived growth factor receptor alpha with a neutralizing human monoclonal antibody inhibits the growth of tumor xenografts: implications as a potential therapeutic target

Loizos, N, Xu, Y, Huber, J, Liu, M, Lu, D, Finnerty, B, Rolser, R, Malikzay, A, Persaud, A, Corcoran, E, Deevi, DS, Balderes, P, Bassi, R, Jimenez, X, Joynes, CJ, Mangalampalli, VR, Steiner, P, Tonra, JR, Wu, Y, Pereira, DS, Zhu, Z, Ludwig, DL, Hicklin, DJ, Bohlen, P, Witte, L, Kussie, P

Mol. Cancer Ther. 2005
20813817 Targeting the {alpha} receptor for platelet-derived growth factor as a primary or combination therapy in a preclinical model of prostate cancer skeletal metastasis

Russell, MR, Liu, Q, Fatatis, A

Clin. Cancer Res. 2010
16331269 Autocrine activation of PDGFRalpha promotes the progression of ovarian cancer

Matei, D, Emerson, RE, Lai, YC, Baldridge, LA, Rao, J, Yiannoutsos, C, Donner, DD

Oncogene 2006
Participants
Participant Of
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created