Reactome | p-11Y-FIP1L1(1-272)-PDGFRA(567-1069) fusion [cytosol]

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p-11Y-FIP1L1(1-272)-PDGFRA(567-1069) fusion [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9673870] p-11Y FIP1L1(1-272):PDGFRA (567-1069) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9673870] p-11Y FIP1L1(1-272):PDGFRA (567-1069) fusion dimer [cytosol] - Homo sapiens
created	[InstanceEdit:9673866] Rothfels, Karen, 2020-01-09
crossReference	[DatabaseIdentifier:12021377] Mondo:0015691
dbId	9673867
disease	[Disease:9672476] hypereosinophilic syndrome
displayName	p-11Y-FIP1L1(1-272)-PDGFRA(567-1069) fusion [cytosol]
endCoordinate	272
hasModifiedResidue	[FragmentInsertionModification:9672464] Insertion of residues 567 to 1089 at 273 from UniProt:P16234 PDGFRA [ModifiedResidue:186764] O4'-phospho-L-tyrosine at 1018 [ModifiedResidue:186779] O4'-phospho-L-tyrosine at 572 [ModifiedResidue:186787] O4'-phospho-L-tyrosine at 574 [ModifiedResidue:186796] O4'-phospho-L-tyrosine at 720 [ModifiedResidue:186782] O4'-phospho-L-tyrosine at 731 [ModifiedResidue:186809] O4'-phospho-L-tyrosine at 742 [ModifiedResidue:186771] O4'-phospho-L-tyrosine at 754 [ModifiedResidue:186823] O4'-phospho-L-tyrosine at 762 [ModifiedResidue:186775] O4'-phospho-L-tyrosine at 768 [ModifiedResidue:186801] O4'-phospho-L-tyrosine at 988 [ModifiedResidue:389089] O4'-phospho-L-tyrosine at 849
inDisease	true
literatureReference	[LiteratureReference:9672488] A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome
maxDepth	1
modified	[InstanceEdit:9832143] Orlic-Milacic, Marija, 2023-03-28
name	p-11Y-FIP1L1(1-272)-PDGFRA(567-1069) fusion
referenceEntity	[ReferenceGeneProduct:uniprot:Q6UN15] UniProt:Q6UN15 FIP1L1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9673867
startCoordinate	1
updateTrackers	[UpdateTracker:9905749] Update Tracker - [EntityWithAccessionedSequence:9673867] p-11Y-FIP1L1(1-272)-PDGFRA(567-1069) fusion [cytosol] - v85:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9905749] Update Tracker - [EntityWithAccessionedSequence:9673867] p-11Y-FIP1L1(1-272)-PDGFRA(567-1069) fusion [cytosol] - v85:[modifyName]
(hasComponent)	[Complex:R-HSA-9673870] p-11Y FIP1L1(1-272):PDGFRA (567-1069) fusion dimer [cytosol]

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