p-11Y-FIP1L1(1-272)-PDGFRA(567-1069) fusion [cytosol]

Stable Identifier
R-HSA-9673867
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
12660384 A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome

Marynen, P, Boogaerts, M, Griffin, JD, Galinsky, I, Cortes, J, Coutré, SE, Kantarjian, H, Schmid, J, Malone, J, Schrier, SL, Cools, J, Stover, EH, Wlodarska, I, Kutok, J, Rose, M, Verhoef, G, Vandenberghe, P, Gotlib, J, Gilliland, DG, Alam, R, Clark, J, Legare, RD, Cross, NC, Stone, R, Deangelo, DJ, Tefferi, A

N. Engl. J. Med. 2003
External Reference Information
External Reference
Gene Names
FIP1L1, FIP1, RHE
Chain
chain:1-594
Other Identifiers
11743936_a_at
11751233_a_at
11759532_at
11759533_s_at
1554424_PM_at
1554424_at
16966748
221007_PM_s_at
221007_s_at
227293_PM_at
227293_at
233405_PM_at
233405_at
2727227
2727228
2727229
2727230
2727231
2727232
2727233
2727234
2727235
2727236
2727238
2727239
2727240
2727241
2727242
2727244
2727245
2727246
2727249
2727252
2727253
2727258
2727259
2727260
2727261
2727262
2727263
2727265
2727268
2727269
2727272
2727273
2727274
2727275
2727276
2727277
2727278
2727279
2727280
2727281
2727282
2727283
2727284
43072_s_at
44003_r_at
58459_s_at
60065_s_at
69587_at
8095048
81608
A_23_P58337
A_24_P20623
A_24_P265162
GE83194
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005829
GO:0005847
GO:0006397
GO:0016071
GO:0043226
HMNXSV003001811
Hs.296735.0.S1_3p_at
Hs.66295.2.A1_3p_at
Hs2.334812.2.S1_3p_s_at
ILMN_1768743
ILMN_2190942
PH_hs_0016478
TC04002930.hg
g13569873_3p_s_at
p28455
p28515
Participates
Other forms of this molecule
Modified Residues
Name
Insertion of residues 567 to 1089 at 273 from UniProt:P16234 PDGFRA
Coordinate
273
Name
O4'-phospho-L-tyrosine at 1018
Coordinate
1018
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 572
Coordinate
572
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 574
Coordinate
574
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 720
Coordinate
720
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 731
Coordinate
731
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 742
Coordinate
742
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 754
Coordinate
754
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 762
Coordinate
762
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 768
Coordinate
768
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 988
Coordinate
988
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 849
Coordinate
849
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Disease
Name Identifier Synonyms
hypereosinophilic syndrome DOID:999 Eosinophilic leukocytosis, eosinophilia
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