Reactome | Signaling by PDGFRA extracellular domain mutants

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Signaling by PDGFRA extracellular domain mutants Show undefined attributes

authored	[InstanceEdit:9677035] Rothfels, Karen, 2020-02-25
created	[InstanceEdit:9673769] Rothfels, Karen, 2020-01-08
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9673770
disease	[Disease:1500689] cancer
displayName	Signaling by PDGFRA extracellular domain mutants
edited	[InstanceEdit:9677035] Rothfels, Karen, 2020-02-25
eventOf	[Pathway:R-HSA-9671555] Signaling by PDGFR in disease - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-9672174] Ligand-independent dimerization of PDGFRA extracellular domain mutants - Homo sapiens [Reaction:R-HSA-9672173] Autophosphorylation of PDGFRA extracellular domain dimers - Homo sapiens [Reaction:R-HSA-9672158] GRB2:SOS1 complex binds to PDGFRA extracellular domain dimers - Homo sapiens [Reaction:R-HSA-9672163] SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers - Homo sapiens [Reaction:R-HSA-9672178] PI3-kinase binds to PDGFRA extracellular domain dimers - Homo sapiens [Reaction:R-HSA-9672162] PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of PDGFRA extracellular domain dimers - Homo sapiens [Reaction:R-HSA-9672159] STAT binds to p-11Y PDGFRA extracellular domain dimers - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9671886] Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies [LiteratureReference:9671907] PDGFRA alterations in cancer: characterization of a gain-of-function V536E transmembrane mutant as well as loss-of-function and passenger mutations [LiteratureReference:9673553] PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas [LiteratureReference:9673539] Novel oncogenic PDGFRA mutations in pediatric high-grade gliomas [LiteratureReference:9673487] A human brain tumor-derived PDGFR-alpha deletion mutant is transforming
maxDepth	2
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Signaling by PDGFRA extracellular domain mutants
normalPathway	[Pathway:R-HSA-186797] Signaling by PDGF
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9676030] Ip, Carman K M, 2020-02-06
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9673770
summation	[Summation:9673750] Mutations in the extracellular domain of receptor tyrosine k...

Referrals

(hasEvent)

[Pathway:R-HSA-9671555] Signaling by PDGFR in disease