Reactome | Autophosphorylation of PDGFRA extracellular domain dimers

Schema > Reaction > Entries

Autophosphorylation of PDGFRA extracellular domain dimers Show undefined attributes

authored	[InstanceEdit:9677035] Rothfels, Karen, 2020-02-25
catalystActivity	[CatalystActivity:9672167] protein tyrosine kinase activity of extracellular domain mutant PDGFRA dimers [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9672161] Rothfels, Karen, 2019-12-23
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9672173
disease	[Disease:1500689] cancer
displayName	Autophosphorylation of PDGFRA extracellular domain dimers
edited	[InstanceEdit:9677035] Rothfels, Karen, 2020-02-25
entityFunctionalStatus	[EntityFunctionalStatus:9672156] gain_of_function of extracellular domain mutant PDGFRA dimers [endoplasmic reticulum membrane]
eventOf	[Pathway:R-HSA-9673770] Signaling by PDGFRA extracellular domain mutants - Homo sapiens
followingEvent	[Reaction:R-HSA-9672159] STAT binds to p-11Y PDGFRA extracellular domain dimers - Homo sapiens [Reaction:R-HSA-9672178] PI3-kinase binds to PDGFRA extracellular domain dimers - Homo sapiens [Reaction:R-HSA-9672158] GRB2:SOS1 complex binds to PDGFRA extracellular domain dimers - Homo sapiens
input	22 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-HSA-9673649] extracellular domain mutant PDGFRA dimers [endoplasmic reticulum membrane]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9673487] A human brain tumor-derived PDGFR-alpha deletion mutant is transforming [LiteratureReference:9673553] PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas [LiteratureReference:9673539] Novel oncogenic PDGFRA mutations in pediatric high-grade gliomas [LiteratureReference:9671886] Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Autophosphorylation of PDGFRA extracellular domain dimers
output	22 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-HSA-9673720] p-11Y PDGFRA extracellular domain dimers [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-9672174] Ligand-independent dimerization of PDGFRA extracellular domain mutants - Homo sapiens
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9676030] Ip, Carman K M, 2020-02-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9672173
summation	[Summation:9673738] Constitutively active extracellular domain mutants of PDGFRA...

Referrals

(hasEvent)	[Pathway:R-HSA-9673770] Signaling by PDGFRA extracellular domain mutants
(precedingEvent)	[Reaction:R-HSA-9672159] STAT binds to p-11Y PDGFRA extracellular domain dimers [Reaction:R-HSA-9672178] PI3-kinase binds to PDGFRA extracellular domain dimers [Reaction:R-HSA-9672158] GRB2:SOS1 complex binds to PDGFRA extracellular domain dimers