Reactome | Ligand-independent dimerization of cytosolic PDGFRA and PDGFRB fusion proteins

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Ligand-independent dimerization of cytosolic PDGFRA and PDGFRB fusion proteins Show undefined attributes

authored	[InstanceEdit:9677035] Rothfels, Karen, 2020-02-25
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9673755] Rothfels, Karen, 2020-01-08
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9673757
disease	[Disease:1500689] cancer
displayName	Ligand-independent dimerization of cytosolic PDGFRA and PDGFRB fusion proteins
edited	[InstanceEdit:9677035] Rothfels, Karen, 2020-02-25
entityFunctionalStatus	[EntityFunctionalStatus:9673668] gain_of_function of cytosolic PDGFR fusions [cytosol]
eventOf	[Pathway:R-HSA-9673766] Signaling by cytosolic PDGFRA and PDGFRB fusion proteins - Homo sapiens
followingEvent	[Reaction:R-HSA-9673756] Autophosphorylation of cytosolic PDGFRA and PDGFRB fusion proteins - Homo sapiens
input	2 × [CandidateSet:R-HSA-9673673] cytosolic PDGFR fusions [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9672488] A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome [LiteratureReference:9673553] PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas [LiteratureReference:9673510] Fusion of PDGFRB to two distinct loci at 3p21 and a third at 12q13 in imatinib-responsive myeloproliferative neoplasms [LiteratureReference:9673580] The platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are major players in oncogenesis, drug resistance, and attractive oncologic targets in cancer [LiteratureReference:9673557] Platelet-derived growth factor receptors (PDGFRs) fusion genes involvement in hematological malignancies [LiteratureReference:9673500] Activation of FIP1L1-PDGFRalpha requires disruption of the juxtamembrane domain of PDGFRalpha and is FIP1L1-independent [LiteratureReference:9673571] Receptor tyrosine kinases in normal and malignant haematopoiesis
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Ligand-independent dimerization of cytosolic PDGFRA and PDGFRB fusion proteins
output	[CandidateSet:R-HSA-9673667] cytosolic PDGFR fusion dimers [cytosol]
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9676030] Ip, Carman K M, 2020-02-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9673757
summation	[Summation:9673742] Fusions of an N-terminal partner and the cytosolic domain of...

Referrals

(precedingEvent)	[Reaction:R-HSA-9673756] Autophosphorylation of cytosolic PDGFRA and PDGFRB fusion proteins
(hasEvent)	[Pathway:R-HSA-9673766] Signaling by cytosolic PDGFRA and PDGFRB fusion proteins

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