Reactome | cytosolic PDGFR fusion dimers [cytosol]

Schema > CandidateSet > Entries

catalystActivities	[CatalystActivity:9673730] protein tyrosine kinase activity of cytosolic PDGFR fusion dimers [cytosol]
compartment	[Compartment:70101] cytosol
consumedByEvent	[Reaction:R-HSA-9673756] Autophosphorylation of cytosolic PDGFRA and PDGFRB fusion proteins - Homo sapiens
created	[InstanceEdit:9673669] Rothfels, Karen, 2020-01-08
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9673667
disease	[Disease:1500689] cancer
displayName	cytosolic PDGFR fusion dimers [cytosol]
hasCandidate	[Complex:R-HSA-9673923] STRN(1-265)-PDGFRA(580-1089) fusion dimer [cytosol] - Homo sapiens
hasMember	[Complex:R-HSA-9673664] WDR48(1-323)-PDGFRB(559-1106) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9673671] FIP1L1(1-395):PDGFRA (585-1069) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9673857] FIP1L1(1-272):PDGFRA (567-1069) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9673861] FIP1L1(1-339):PDGFRA (580-1069) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9673863] FIP1L1(1-395):PDGFRA (577-1069) fusion dimer [cytosol] - Homo sapiens
inDisease	true
maxDepth	3
modified	[InstanceEdit:9673938] Rothfels, Karen, 2020-01-09
name	cytosolic PDGFR fusion dimers
producedByEvent	[Reaction:R-HSA-9673757] Ligand-independent dimerization of cytosolic PDGFRA and PDGFRB fusion proteins - Homo sapiens
schemaClass	CandidateSet
species	[Species:48887] Homo sapiens
stId	R-HSA-9673667

(input)	[Reaction:R-HSA-9673756] Autophosphorylation of cytosolic PDGFRA and PDGFRB fusion proteins
(diseaseEntity)	[EntityFunctionalStatus:9673676] gain_of_function of cytosolic PDGFR fusion dimers [cytosol]
(physicalEntity)	[CatalystActivity:9673730] protein tyrosine kinase activity of cytosolic PDGFR fusion dimers [cytosol]
(output)	[Reaction:R-HSA-9673757] Ligand-independent dimerization of cytosolic PDGFRA and PDGFRB fusion proteins