Reactome | Autophosphorylation of cytosolic PDGFRA and PDGFRB fusion proteins

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Autophosphorylation of cytosolic PDGFRA and PDGFRB fusion proteins Show undefined attributes

authored	[InstanceEdit:9677035] Rothfels, Karen, 2020-02-25
catalystActivity	[CatalystActivity:9673730] protein tyrosine kinase activity of cytosolic PDGFR fusion dimers [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9673755] Rothfels, Karen, 2020-01-08
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9673756
disease	[Disease:1500689] cancer
displayName	Autophosphorylation of cytosolic PDGFRA and PDGFRB fusion proteins
edited	[InstanceEdit:9677035] Rothfels, Karen, 2020-02-25
entityFunctionalStatus	[EntityFunctionalStatus:9673676] gain_of_function of cytosolic PDGFR fusion dimers [cytosol]
eventOf	[Pathway:R-HSA-9673766] Signaling by cytosolic PDGFRA and PDGFRB fusion proteins - Homo sapiens
input	12 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [CandidateSet:R-HSA-9673667] cytosolic PDGFR fusion dimers [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9672488] A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome [LiteratureReference:9673500] Activation of FIP1L1-PDGFRalpha requires disruption of the juxtamembrane domain of PDGFRalpha and is FIP1L1-independent [LiteratureReference:9673492] A novel FIP1L1-PDGFRA mutant destabilizing the inactive conformation of the kinase domain in chronic eosinophilic leukemia/hypereosinophilic syndrome [LiteratureReference:9673571] Receptor tyrosine kinases in normal and malignant haematopoiesis [LiteratureReference:9673580] The platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are major players in oncogenesis, drug resistance, and attractive oncologic targets in cancer [LiteratureReference:9673557] Platelet-derived growth factor receptors (PDGFRs) fusion genes involvement in hematological malignancies
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Autophosphorylation of cytosolic PDGFRA and PDGFRB fusion proteins
output	12 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [CandidateSet:R-HSA-9673719] cytosolic p-Y PDGFR fusion dimers [cytosol]
precedingEvent	[Reaction:R-HSA-9673757] Ligand-independent dimerization of cytosolic PDGFRA and PDGFRB fusion proteins - Homo sapiens
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9676030] Ip, Carman K M, 2020-02-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9673756
summation	[Summation:9673856] Where examined, cytosolic fusion proteins of PDGFRA and B ha...

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[Pathway:R-HSA-9673766] Signaling by cytosolic PDGFRA and PDGFRB fusion proteins

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