PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of mutant PDGFR

Stable Identifier
R-HSA-9672177
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of mutant PDGFR
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PI3K/AKT signaling is initiated downstream of PDGFRA gain-of-function missense and in-frame deletion mutants as assessed by the presence of phosphorylated AKT in Western blot analysis (Heinrich et al, 2003; Osashi et al, 2005; Bahlawane et al, 2015; Paugh et al, 2013; reviewed in Corless et al, 2011).
Literature References
PubMed ID Title Journal Year
22089421 Gastrointestinal stromal tumours: origin and molecular oncology

Corless, CL, Barnett, CM, Heinrich, MC

Nat. Rev. Cancer 2011
15221957 Different inhibitory effect of imatinib on phosphorylation of mitogen-activated protein kinase and Akt and on proliferation in cells expressing different types of mutant platelet-derived growth factor receptor-alpha

Ohashi, A, Kinoshita, K, Isozaki, K, Nishida, T, Shinomura, Y, Kitamura, Y, Hirota, S

Int. J. Cancer 2004
12522257 PDGFRA activating mutations in gastrointestinal stromal tumors

Heinrich, MC, Corless, CL, Duensing, A, McGreevey, L, Chen, CJ, Joseph, N, Singer, S, Griffith, DJ, Haley, A, Town, A, Demetri, GD, Fletcher, CD, Fletcher, JA

Science 2003
25880691 Constitutive activation of oncogenic PDGFRα-mutant proteins occurring in GIST patients induces receptor mislocalisation and alters PDGFRα signalling characteristics

Bahlawane, C, Eulenfeld, R, Wiesinger, MY, Wang, J, Muller, A, Girod, A, Nazarov, PV, Felsch, K, Vallar, L, Sauter, T, Satagopam, VP, Haan, S

Cell Commun. Signal 2015
23970477 Novel oncogenic PDGFRA mutations in pediatric high-grade gliomas

Paugh, BS, Zhu, X, Qu, C, Endersby, R, Diaz, AK, Zhang, J, Bax, DA, Carvalho, D, Reis, RM, Onar-Thomas, A, Broniscer, A, Wetmore, C, Zhang, J, Jones, C, Ellison, DW, Baker, SJ

Cancer Res. 2013
Participants
Input
Output
Participates
as an event of
Catalyst Activity

1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of p-11Y PDGFR mutant dimers:PI3K [plasma membrane]

Physical Entity
p-11Y PDGFR mutant dimers:PI3K [plasma membrane] (Homo sapiens)
Activity
1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934)
Normal reaction
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Homo sapiens)
Functional status

Gain of function of p-11Y PDGFR mutant dimers:PI3K [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
RHEA
Mondo
Authored
Rothfels, K  (2020-02-25)
Reviewed
Ip, CKM  (2020-02-06)
Created
Rothfels, K  (2019-12-23)
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