PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of mutant PDGFR

Stable Identifier
Reaction [transition]
Homo sapiens
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PI3K/AKT signaling is initiated downstream of PDGFRA gain-of-function missense and in-frame deletion mutants as assessed by the presence of phosphorylated AKT in Western blot analysis (Heinrich et al, 2003; Osashi et al, 2005; Bahlawane et al, 2015; Paugh et al, 2013; reviewed in Corless et al, 2011).
Literature References
PubMed ID Title Journal Year
22089421 Gastrointestinal stromal tumours: origin and molecular oncology

Barnett, CM, Corless, CL, Heinrich, MC

Nat. Rev. Cancer 2011
15221957 Different inhibitory effect of imatinib on phosphorylation of mitogen-activated protein kinase and Akt and on proliferation in cells expressing different types of mutant platelet-derived growth factor receptor-alpha

Kitamura, Y, Shinomura, Y, Isozaki, K, Nishida, T, Kinoshita, K, Ohashi, A, Hirota, S

Int. J. Cancer 2004
12522257 PDGFRA activating mutations in gastrointestinal stromal tumors

Corless, CL, Heinrich, MC, Singer, S, Griffith, DJ, Town, A, Haley, A, Duensing, A, McGreevey, L, Fletcher, JA, Demetri, GD, Joseph, N, Chen, CJ, Fletcher, CD

Science 2003
25880691 Constitutive activation of oncogenic PDGFRα-mutant proteins occurring in GIST patients induces receptor mislocalisation and alters PDGFRα signalling characteristics

Muller, A, Satagopam, VP, Girod, A, Sauter, T, Haan, S, Eulenfeld, R, Vallar, L, Wang, J, Nazarov, PV, Bahlawane, C, Wiesinger, MY, Felsch, K

Cell Commun. Signal 2015
23970477 Novel oncogenic PDGFRA mutations in pediatric high-grade gliomas

Diaz, AK, Zhang, J, Broniscer, A, Zhang, J, Zhu, X, Baker, SJ, Reis, RM, Endersby, R, Bax, DA, Carvalho, D, Wetmore, C, Qu, C, Ellison, DW, Jones, C, Paugh, BS, Onar-Thomas, A

Cancer Res. 2013
Catalyst Activity

phosphatidylinositol-4,5-bisphosphate 3-kinase activity of p-11Y PDGFR mutant dimers:PI3K [plasma membrane]

Normal reaction
Functional status

Gain of function of p-11Y PDGFR mutant dimers:PI3K [plasma membrane]

Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
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