Reactome | midostaurin sensitive KIT mutants [plasma membrane]

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midostaurin sensitive KIT mutants [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9669739] Rothfels, Karen, 2019-12-03
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9669738
disease	[Disease:1500689] cancer
displayName	midostaurin sensitive KIT mutants [plasma membrane]
hasMember	[EntityWithAccessionedSequence:R-HSA-9669551] KIT V559D [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9669569] KIT V560G [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9669452] KIT D816V [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9669435] KIT D816Y [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9669464] KIT N822K [plasma membrane] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:9669059] Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412 [LiteratureReference:9671344] Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation [LiteratureReference:9671383] PKC412 inhibits in vitro growth of neoplastic human mast cells expressing the D816V-mutated variant of KIT: comparison with AMN107, imatinib, and cladribine (2CdA) and evaluation of cooperative drug effects
maxDepth	2
memberOf	[DefinedSet:R-HSA-9671496] type TKI sensitive KIT mutants [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9671501] Rothfels, Karen, 2019-12-19
name	midostaurin sensitive KIT mutants
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-9669738

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[DefinedSet:R-HSA-9671496] type TKI sensitive KIT mutants [plasma membrane]

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