midostaurin sensitive KIT mutants [plasma membrane]

Stable Identifier
Set [DefinedSet]
Homo sapiens
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
15972446 Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation

Gotlib, J, Berubé, C, Growney, JD, Chen, CC, George, TI, Williams, C, Kajiguchi, T, Ruan, J, Lilleberg, SL, Durocher, JA, Lichy, JH, Wang, Y, Cohen, PS, Arber, DA, Heinrich, MC, Neckers, L, Galli, SJ, Gilliland, DG, Coutré, SE

Blood 2005
16189265 PKC412 inhibits in vitro growth of neoplastic human mast cells expressing the D816V-mutated variant of KIT: comparison with AMN107, imatinib, and cladribine (2CdA) and evaluation of cooperative drug effects

Gleixner, KV, Mayerhofer, M, Aichberger, KJ, Derdak, S, Sonneck, K, Böhm, A, Gruze, A, Samorapoompichit, P, Manley, PW, Fabbro, D, Pickl, WF, Sillaber, C, Valent, P

Blood 2006
15790786 Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412

Growney, JD, Clark, JJ, Adelsperger, J, Stone, R, Fabbro, D, Griffin, JD, Gilliland, DG

Blood 2005
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
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