ALK binds ligand midkine (MDK)

Stable Identifier
R-HSA-9667914
Type
Reaction
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
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ALK binds ligand midkine (MDK)
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ALK receptor tyrosine kinase binds to secreted growth factor midkine (MDK), homologous to pleiotrophin (PTN) (Stoica et al, 2002). MDK activates PI3K signaling (Stoica et al. 2002) and IRS1/NFKB signaling (Kuo et al, 2007) downstream of ALK.

Literature References
PubMed ID Title Journal Year
12122009 Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types

Wellstein, A, Kuo, AH, Stoica, GE, Riegel, AT, Bowden, ET, Sale, EB, Powers, C

J. Biol. Chem. 2002
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Authored
Orlic-Milacic, M  (2019-11-18)
Reviewed
Inghirami, G  (2021-05-04)
Created
Orlic-Milacic, M  (2019-11-18)
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