Reactome | BIL binds GSTA1, FABP1

Schema > Reaction > Entries

BIL binds GSTA1, FABP1 Show undefined attributes

authored	[InstanceEdit:9663503] Jassal, Bijay, 2019-10-02
catalystActivity	[CatalystActivity:9955861] molecular carrier activity of GSTA1, FABP1 [cytosol]
catalystActivityReference	[CatalystActivityReference:9955849] molecular carrier activity of GSTA1, FABP1 [cytosol] Bilirubin binding to human liver ligandin (glutathione S-transferase)
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9663503] Jassal, Bijay, 2019-10-02
dbId	9663511
displayName	BIL binds GSTA1, FABP1
edited	[InstanceEdit:9663503] Jassal, Bijay, 2019-10-02
eventOf	[Pathway:R-HSA-189483] Heme degradation - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9663492] BIL dissociates from GSTA1, FABP1 - Homo sapiens
input	[SimpleEntity:R-ALL-189386] BIL [cytosol] [DefinedSet:R-HSA-9663507] GSTA1, FABP1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9663504] Bilirubin binding to human liver ligandin (glutathione S-transferase) [LiteratureReference:9663508] Two hepatic cytoplasmic protein fractions, Y and Z, and their possible role in the hepatic uptake of bilirubin, sulfobromophthalein, and other anions
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	BIL binds GSTA1, FABP1
negativePrecedingEvent	[NegativePrecedingEvent:9955846] Futile Cycle: BIL dissociates from GSTA1, FABP1 [NegativePrecedingEvent:9955850] BLVRA:Zn2+, BLVRB reduce BV to BIL
orthologousEvent	[Reaction:R-CEL-9663511] BIL binds GSTA1, FABP1 - Caenorhabditis elegans [Reaction:R-DME-9663511] BIL binds GSTA1, FABP1 - Drosophila melanogaster [Reaction:R-GGA-9663511] BIL binds GSTA1, FABP1 - Gallus gallus [Reaction:R-XTR-9663511] BIL binds GSTA1, FABP1 - Xenopus tropicalis [Reaction:R-DRE-9663511] BIL binds GSTA1, FABP1 - Danio rerio [Reaction:R-SSC-9663511] BIL binds GSTA1, FABP1 - Sus scrofa [Reaction:R-BTA-9663511] BIL binds GSTA1, FABP1 - Bos taurus [Reaction:R-CFA-9663511] BIL binds GSTA1, FABP1 - Canis familiaris [Reaction:R-RNO-9663511] BIL binds GSTA1, FABP1 - Rattus norvegicus [Reaction:R-MMU-9663511] BIL binds GSTA1, FABP1 - Mus musculus
output	[Complex:R-HSA-9663490] BIL:GSTA1, FABP1 [cytosol]
precedingEvent	[Reaction:R-HSA-9661397] SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) - Homo sapiens [Reaction:R-HSA-9661799] SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) - Homo sapiens [Reaction:R-HSA-9661723] SLCO2B1-3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2019-12-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9663548] D'Eustachio, Peter, 2019-10-03 [InstanceEdit:9963235] Hill, David P, 2025-08-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9663511
summation	[Summation:9663491] Upon entry into the hepatocyte, bilirubin (BIL) can bind to ...
updateTrackers	[UpdateTracker:9964793] Update Tracker - [Reaction:9663511] BIL binds GSTA1, FABP1 - v94:[removeCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9964793] Update Tracker - [Reaction:9663511] BIL binds GSTA1, FABP1 - v94:[removeCatalystActivity]
(hasEvent)	[Pathway:R-HSA-189483] Heme degradation
(precedingEvent)	[BlackBoxEvent:R-HSA-9663492] BIL dissociates from GSTA1, FABP1