BIL binds GSTA1, FABP1

Stable Identifier
R-HSA-9663511
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Upon entry into the hepatocyte, bilirubin (BIL) can bind to one of two cytosolic binding proteins; glutathione S-transferase A1 (GSTA1 aka ligandin, Y-protein), a major cytosolic protein that has both transport and detoxification functions or fatty acid-binding protein (FABP1 aka Z-protein) (Levi et al. 1969, Simons & Jagt 1980, Arias 2012). It is assumed GSTA1 transports BIL to the ER where it is detoxified by conjugation with a glucuronosyl moiety.

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