Reactome | p-T185,Y187 MAPK1 D321N [cytosol]

Schema > EntityWithAccessionedSequence > Entries

p-T185,Y187 MAPK1 D321N [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9652784] Rothfels, Karen, 2019-07-03
crossReference	[DatabaseIdentifier:12020747] Mondo:0010150 [DatabaseIdentifier:9652708] COSMIC:COSV53186174
dbId	9652785
disease	[Disease:1248679] head and neck squamous cell carcinoma
displayName	p-T185,Y187 MAPK1 D321N [cytosol]
endCoordinate	360
hasModifiedResidue	[ReplacedResidue:9652767] L-aspartic acid 321 replaced with L-asparagine [ModifiedResidue:3006594] O-phospho-L-threonine at 185 [ModifiedResidue:109851] O4'-phospho-L-tyrosine at 187
inDisease	true
literatureReference	[LiteratureReference:9652693] Phenotypic Characterization of a Comprehensive Set of MAPK1/ERK2 Missense Mutants [LiteratureReference:9652722] Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1
maxDepth	1
memberOf	[CandidateSet:R-HSA-9652813] constitutively active MAPK1 mutants [cytosol] - Homo sapiens
name	p-T185,Y187 MAPK1 D321N ERK2 Mitogen-activated protein kinase 1 (EC 2.7.1.-) (Extracellular signal- regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1) Mitogen-activated protein kinase 1 Extracellular signal-regulated kinase 2 Mitogen-activated protein kinase 2 MAP kinase 2 MAPK 2 p42-MAPK ERT1 ERK-2
referenceEntity	[ReferenceGeneProduct:uniprot:P28482] UniProt:P28482 MAPK1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9652785
startCoordinate	2

Referrals

(hasMember)

[CandidateSet:R-HSA-9652813] constitutively active MAPK1 mutants [cytosol]

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