Reactome | constitutively active MAPK1 mutants [cytosol]

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constitutively active MAPK1 mutants [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
consumedByEvent	[FailedReaction:R-HSA-9652816] Constitutively active MAPK1 mutants are not dephosphorylated by DUSPs - Homo sapiens
created	[InstanceEdit:9652811] Rothfels, Karen, 2019-07-03
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9652813
disease	[Disease:1500689] cancer
displayName	constitutively active MAPK1 mutants [cytosol]
hasCandidate	[EntityWithAccessionedSequence:R-HSA-9652794] p-T185,Y187 MAPK1 E322A [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9652802] p-T185,Y187 MAPK1 P58G [cytosol] - Homo sapiens
hasMember	[EntityWithAccessionedSequence:R-HSA-9652785] p-T185,Y187 MAPK1 D321N [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9652791] p-T185,Y187 MAPK1 D321V [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9652797] p-T185,Y187 MAPK1 E322V [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9652799] p-T185,Y187 MAPK1 E81K [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9652806] p-T185,Y187 MAPK1 P58L [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9652808] p-T185,Y187 MAPK1 S142L [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9652175] p-T185,Y187 MAPK1 E322K [cytosol] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:9652693] Phenotypic Characterization of a Comprehensive Set of MAPK1/ERK2 Missense Mutants
maxDepth	2
name	constitutively active MAPK1 mutants
schemaClass	CandidateSet
species	[Species:48887] Homo sapiens
stId	R-HSA-9652813

Referrals

(input)	[FailedReaction:R-HSA-9652816] Constitutively active MAPK1 mutants are not dephosphorylated by DUSPs
(diseaseEntity)	[EntityFunctionalStatus:9652812] loss_of_function of constitutively active MAPK1 mutants [cytosol]

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