Reactome | RAS GAP mutants aren't stimulated by GAPs

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RAS GAP mutants aren't stimulated by GAPs Show undefined attributes

category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9651283] Rothfels, Karen, 2019-06-25
crossReference	[DatabaseIdentifier:12020780] Mondo:0015280
dbId	9651280
disease	[Disease:1500689] cancer [Disease:9651119] cardiofaciocutaneous syndrome
displayName	RAS GAP mutants aren't stimulated by GAPs
entityFunctionalStatus	[EntityFunctionalStatus:9651308] loss_of_function of RAS GAP mutants:GTP [plasma membrane]
eventOf	[Pathway:R-HSA-9753510] Signaling by RAS GAP mutants - Homo sapiens
input	[Complex:R-HSA-9651282] RAS GAP mutants:GTP [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:5658433] Structural fingerprints of the Ras-GTPase activating proteins neurofibromin and p120GAP [LiteratureReference:5658404] Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras [LiteratureReference:2685012] GEFs and GAPs: critical elements in the control of small G proteins [LiteratureReference:6790229] A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants [LiteratureReference:6790428] The pre-hydrolysis state of p21(ras) in complex with GTP: new insights into the role of water molecules in the GTP hydrolysis reaction of ras-like proteins [LiteratureReference:6790233] Allosteric modulation of Ras positions Q61 for a direct role in catalysis [LiteratureReference:208211] The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants [LiteratureReference:6790423] The RASopathies [LiteratureReference:6790425] The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation [LiteratureReference:6790346] Germline KRAS mutations cause Noonan syndrome [LiteratureReference:6790237] Biochemical and functional characterization of germ line KRAS mutations
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RAS GAP mutants aren't stimulated by GAPs
normalReaction	[Reaction:R-HSA-5658435] RAS GAPs bind RAS:GTP
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8933498] Stephens, Robert M, 2016-08-05
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9651280
summation	[Summation:9658308] RAS GAP proteins interact with RAS by inserting an arginine ...

Referrals

(hasEvent)

[Pathway:R-HSA-9753510] Signaling by RAS GAP mutants