Reactome | Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2

Schema > Reaction > Entries

Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 Show undefined attributes

authored	[InstanceEdit:749521] Dall'Olio, GM, 2009-11-10
catalystActivity	[CatalystActivity:964728] mannosyl-oligosaccharide 1,2-alpha-mannosidase activity of MAN1A1/A2/C1 [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen
created	[InstanceEdit:964826] Jassal, B, 2010-09-17
dbId	964825
displayName	Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2
edited	[InstanceEdit:964826] Jassal, B, 2010-09-17
eventOf	[Pathway:R-HSA-964827] Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 - Homo sapiens
followingEvent	[Reaction:R-HSA-964768] Addition of GlcNAc to the glycan on the A arm - Homo sapiens
input	[DefinedSet:R-ALL-964831] (GlcNAc)2 (Man)8 glycans [Golgi lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:964748] Characterization of a cDNA encoding a novel human Golgi alpha 1, 2-mannosidase (IC) involved in N-glycan biosynthesis
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2
orthologousEvent	[Reaction:R-BTA-964825] Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 - Bos taurus [Reaction:R-DDI-964825] Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 - Dictyostelium discoideum [Reaction:R-CEL-964825] Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 - Caenorhabditis elegans [Reaction:R-DME-964825] Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 - Drosophila melanogaster [Reaction:R-GGA-964825] Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 - Gallus gallus [Reaction:R-XTR-964825] Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 - Xenopus tropicalis [Reaction:R-DRE-964825] Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 - Danio rerio [Reaction:R-SSC-964825] Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 - Sus scrofa [Reaction:R-CFA-964825] Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 - Canis familiaris [Reaction:R-RNO-964825] Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 - Rattus norvegicus [Reaction:R-MMU-964825] Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 - Mus musculus
output	[SimpleEntity:R-ALL-964740] (GlcNAc)2 (Man)5 (Asn)1 [Golgi lumen] 3 × [SimpleEntity:R-ALL-964752] Man [Golgi lumen]
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1028799] Gagneux, P, 2010-11-18
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-964825
summation	[Summation:964733] In the cis-Golgi, Man7, Man8 or Man9 N-glycans are progressi...

Referrals

(precedingEvent)	[Reaction:R-HSA-964768] Addition of GlcNAc to the glycan on the A arm
(hasEvent)	[Pathway:R-HSA-964827] Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2