Reactome | Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2

Schema > Reaction > Entries

Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 Show undefined attributes

catalystActivity	[CatalystActivity:11014272] mannosyl-oligosaccharide 1,2-alpha-mannosidase activity of MAN1A1/A2/C1 [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11014284
displayName	Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2
eventOf	[Pathway:R-DDI-964827] Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DDI-964768] Addition of GlcNAc to the glycan on the A arm - Dictyostelium discoideum
inferredFrom	[Reaction:R-HSA-964825] Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 - Homo sapiens
input	[DefinedSet:R-ALL-964831] (GlcNAc)2 (Man)8 glycans [Golgi lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2
output	[SimpleEntity:R-ALL-964740] (GlcNAc)2 (Man)5 (Asn)1 [Golgi lumen] 3 × [SimpleEntity:R-ALL-964752] Man [Golgi lumen]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-964825
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-DDI-964768] Addition of GlcNAc to the glycan on the A arm
(hasEvent)	[Pathway:R-DDI-964827] Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2
(inferredTo)	[Reaction:R-HSA-964825] Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2

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