Reactome | NEK6 and NEK7 phosphorylate EML4

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NEK6 and NEK7 phosphorylate EML4 Show undefined attributes

authored	[InstanceEdit:9651264] Orlic-Milacic, Marija, 2019-06-25
catalystActivity	[CatalystActivity:2990918] protein serine/threonine kinase activity of p-3S,2T-NEK9: p-S206-NEK6/ p-S195-NEK7 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9648098] Orlic-Milacic, Marija, 2019-06-04
dbId	9648089
displayName	NEK6 and NEK7 phosphorylate EML4
edited	[InstanceEdit:9663595] Orlic-Milacic, Marija, 2019-10-07
eventOf	[Pathway:R-HSA-9648025] EML4 and NUDC in mitotic spindle formation - Homo sapiens
input	6 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-9647745] EML4 homotrimer [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9648018] Human EML4, a novel member of the EMAP family, is essential for microtubule formation [LiteratureReference:9663521] Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	NEK6 and NEK7 phosphorylate EML4
orthologousEvent	[Reaction:R-BTA-9648089] NEK6 and NEK7 phosphorylate EML4 - Bos taurus [Reaction:R-GGA-9648089] NEK6 and NEK7 phosphorylate EML4 - Gallus gallus [Reaction:R-XTR-9648089] NEK6 and NEK7 phosphorylate EML4 - Xenopus tropicalis [Reaction:R-SSC-9648089] NEK6 and NEK7 phosphorylate EML4 - Sus scrofa [Reaction:R-CFA-9648089] NEK6 and NEK7 phosphorylate EML4 - Canis familiaris
output	6 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-9648091] p-S,T-EML4 homotrimer [cytosol]
precedingEvent	[Reaction:R-HSA-9647746] EML4 trimerizes - Homo sapiens [Reaction:R-HSA-2984258] NEK9 phosphorylates NEK6/NEK7 - Homo sapiens
releaseDate	2019-12-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9663562] Fry, Andrew M, 2019-09-30 [InstanceEdit:9663558] Lucken, Kellie, 2019-09-30 [InstanceEdit:9663559] O'Regan, Laura, 2019-09-30 [InstanceEdit:9663574] Bechstedt, Susanne, 2019-10-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9648089
summation	[Summation:9648104] At mitotic entry, EML4 undergoes phosphorylation on serine a...

Referrals

(hasEvent)

[Pathway:R-HSA-9648025] EML4 and NUDC in mitotic spindle formation