Reactome | NEK6 and NEK7 phosphorylate EML4

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NEK6 and NEK7 phosphorylate EML4 Show undefined attributes

catalystActivity	[CatalystActivity:10390969] protein serine/threonine kinase activity of p-3S,2T-NEK9: p-S206-NEK6/ p-S195-NEK7 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10433326
displayName	NEK6 and NEK7 phosphorylate EML4
eventOf	[Pathway:R-BTA-9648025] EML4 and NUDC in mitotic spindle formation - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9648089] NEK6 and NEK7 phosphorylate EML4 - Homo sapiens
input	6 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-BTA-9647745] EML4 homotrimer [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	NEK6 and NEK7 phosphorylate EML4
output	6 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-BTA-9648091] p-S,T-EML4 homotrimer [cytosol]
precedingEvent	[Reaction:R-BTA-9647746] EML4 trimerizes - Bos taurus [Reaction:R-BTA-2984258] NEK9 phosphorylates NEK6/NEK7 - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-9648089
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-9648025] EML4 and NUDC in mitotic spindle formation
(inferredTo)	[Reaction:R-HSA-9648089] NEK6 and NEK7 phosphorylate EML4

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