NEK6 and NEK7 phosphorylate EML4

Stable Identifier
R-HSA-9648089
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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At mitotic entry, EML4 undergoes phosphorylation on serine and/or threonine residues (Pollmann et al. 2006). NEK6 and NEK7 serine/threonine kinases phosphorylate EML4 at evolutionarily conserved serine residues S144 and S146. Phosphorylation of EML4 at S144 and S146 reduces the affinity of EML4 for microtubules, leading to an increase in microtubule instability that is necessary for the assembly of a dynamic mitotic spindle and successful segregation of duplicated chromosomes (Adib et al. 2019).

Literature References
PubMed ID Title Journal Year
16890222 Human EML4, a novel member of the EMAP family, is essential for microtubule formation

Pollmann, M, Parwaresch, R, Adam-Klages, S, Kruse, ML, Buck, F, Heidebrecht, HJ

Exp. Cell Res. 2006
31409757 Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression

Adib, R, Montgomery, JM, Atherton, J, O'Regan, L, Richards, MW, Straatman, KR, Roth, D, Straube, A, Bayliss, R, Moores, CA, Fry, AM

Sci Signal 2019
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-3S,2T-NEK9: p-S206-NEK6/ p-S195-NEK7 [cytosol]
Physical Entity
Activity
Orthologous Events
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Created