Reactome | NEK6 and NEK7 phosphorylate EML4

NEK6 and NEK7 phosphorylate EML4

Stable Identifier

R-HSA-9648089

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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At mitotic entry, EML4 undergoes phosphorylation on serine and/or threonine residues (Pollmann et al. 2006). NEK6 and NEK7 serine/threonine kinases phosphorylate EML4 at evolutionarily conserved serine residues S144 and S146. Phosphorylation of EML4 at S144 and S146 reduces the affinity of EML4 for microtubules, leading to an increase in microtubule instability that is necessary for the assembly of a dynamic mitotic spindle and successful segregation of duplicated chromosomes (Adib et al. 2019).

Literature References

PubMed ID	Title	Journal	Year
31409757	Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression Adib, R, Montgomery, JM, Atherton, J, O'Regan, L, Richards, MW, Straatman, KR, Roth, D, Straube, A, Bayliss, R, Moores, CA, Fry, AM	Sci Signal	2019
16890222	Human EML4, a novel member of the EMAP family, is essential for microtubule formation Pollmann, M, Parwaresch, R, Adam-Klages, S, Kruse, ML, Buck, F, Heidebrecht, HJ	Exp. Cell Res.	2006