Reactome | ERBB2 T798M [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

ERBB2 T798M [plasma membrane] Show undefined attributes

candidateOf	[CandidateSet:R-HSA-9649462] ERBB2 KD mutants (AZ5104) [plasma membrane] - Homo sapiens
compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9665313] ERBB2 T798M:ERBIN:HSP90:CDC37 [plasma membrane] - Homo sapiens
created	[InstanceEdit:9646826] Orlic-Milacic, Marija, 2019-05-29
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9646825
disease	[Disease:1500689] cancer
displayName	ERBB2 T798M [plasma membrane]
endCoordinate	1255
hasModifiedResidue	[ReplacedResidue:9646815] L-threonine 798 replaced with L-methionine
inDisease	true
literatureReference	[LiteratureReference:9647026] An Acquired HER2^T798I Gatekeeper Mutation Induces Resistance to Neratinib in a Patient with HER2 Mutant-Driven Breast Cancer
maxDepth	1
memberOf	[DefinedSet:R-HSA-9665272] ERBB2 KD mutants (neratinib resistant) [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9665271] ERBB2 KD mutants (AEE788 resistant) [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9665282] ERBB2 KD mutants (lapatinib resistant) [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9665226] ERBB2 KD mutants (trastuzumab resistant) [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9664578] ERBB2 KD mutants (EGFR,ERBB3) [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9646481] ERBB2 KD mutants [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9647027] Orlic-Milacic, Marija, 2019-05-29
name	ERBB2 T798M HER2 T798M ERBB2 Thr798Met HER2 Thr798Met
referenceEntity	[ReferenceGeneProduct:uniprot:P04626] UniProt:P04626 ERBB2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9646825
startCoordinate	23

Referrals

(hasMember)	[DefinedSet:R-HSA-9665272] ERBB2 KD mutants (neratinib resistant) [plasma membrane] [DefinedSet:R-HSA-9665274] ERBB2 KD mutants (osimertinib resistant) [plasma membrane] [CandidateSet:R-HSA-9665226] ERBB2 KD mutants (trastuzumab resistant) [plasma membrane] [DefinedSet:R-HSA-9665271] ERBB2 KD mutants (AEE788 resistant) [plasma membrane] [CandidateSet:R-HSA-9665282] ERBB2 KD mutants (lapatinib resistant) [plasma membrane] [CandidateSet:R-HSA-9646481] ERBB2 KD mutants [plasma membrane] [CandidateSet:R-HSA-9664578] ERBB2 KD mutants (EGFR,ERBB3) [plasma membrane]
(hasComponent)	[Complex:R-HSA-9665313] ERBB2 T798M:ERBIN:HSP90:CDC37 [plasma membrane]
(hasCandidate)	[CandidateSet:R-HSA-9649462] ERBB2 KD mutants (AZ5104) [plasma membrane]