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Schema
>
Polymerisation
>
Entries
Ub:misfolded proteins polymerize to PolyUb:misfolded proteins
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authored
[InstanceEdit:9641107] Varusai, Thawfeek, 2019-04-04
category
binding
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:9641131] Varusai, Thawfeek, 2019-04-04
dbId
9641127
displayName
Ub:misfolded proteins polymerize to PolyUb:misfolded proteins
edited
[InstanceEdit:9667290] Varusai, Thawfeek, 2019-11-08
eventOf
[Pathway:R-HSA-9646399] Aggrephagy - Homo sapiens
followingEvent
[Reaction:R-HSA-9641109] PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 - Homo sapiens
input
[Complex:R-HSA-9641130] Ub:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9641088] Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6
maxDepth
1
modified
[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name
Ub:misfolded proteins polymerize to PolyUb:misfolded proteins
orthologousEvent
[Polymerisation:R-PFA-9641127] Ub:misfolded proteins polymerize to PolyUb:misfolded proteins - Plasmodium falciparum
[Polymerisation:R-SCE-9641127] Ub:misfolded proteins polymerize to PolyUb:misfolded proteins - Saccharomyces cerevisiae
[Polymerisation:R-DDI-9641127] Ub:misfolded proteins polymerize to PolyUb:misfolded proteins - Dictyostelium discoideum
[Polymerisation:R-CEL-9641127] Ub:misfolded proteins polymerize to PolyUb:misfolded proteins - Caenorhabditis elegans
[Polymerisation:R-DME-9641127] Ub:misfolded proteins polymerize to PolyUb:misfolded proteins - Drosophila melanogaster
[Polymerisation:R-DRE-9641127] Ub:misfolded proteins polymerize to PolyUb:misfolded proteins - Danio rerio
[Polymerisation:R-SSC-9641127] Ub:misfolded proteins polymerize to PolyUb:misfolded proteins - Sus scrofa
[Polymerisation:R-BTA-9641127] Ub:misfolded proteins polymerize to PolyUb:misfolded proteins - Bos taurus
[Polymerisation:R-CFA-9641127] Ub:misfolded proteins polymerize to PolyUb:misfolded proteins - Canis familiaris
[Polymerisation:R-RNO-9641127] Ub:misfolded proteins polymerize to PolyUb:misfolded proteins - Rattus norvegicus
[Polymerisation:R-MMU-9641127] Ub:misfolded proteins polymerize to PolyUb:misfolded proteins - Mus musculus
output
[Complex:R-HSA-9641113] PolyUb:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol]
precedingEvent
[Reaction:R-HSA-9641111] Parkin transfers Ub to misfolded proteins - Homo sapiens
releaseDate
2019-12-10
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9682018] Metzakopian, Emmanouil, 2019-05-24
schemaClass
Polymerisation
species
[Species:48887] Homo sapiens
stId
R-HSA-9641127
summation
[Summation:9641116] Misfolded proteins in the cytosol are targeted to degradatio...
Referrals
(hasEvent)
[Pathway:R-HSA-9646399] Aggrephagy
(precedingEvent)
[Reaction:R-HSA-9641109] PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1
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