Ub:misfolded proteins polymerize to PolyUb:misfolded proteins

Stable Identifier
R-HSA-9641127
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Ub:misfolded proteins polymerize to PolyUb:misfolded proteins
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Misfolded proteins in the cytosol are targeted to degradation via ubiquitination. The E2 UBE2N/UBE2V1 and E3 ligase ubiquitination system recruits and transfers ubiquitin molecules to misfolded proteins. The E3 ligase Parkin tags the proteins with multiple K63-linked ubiquitin molecules (Olzmann JA et al. 2007).
Literature References
PubMed ID Title Journal Year
17846173 Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6

Chin, LS, Palmiter, RD, Chudaev, MV, Perez, FA, Olzmann, JA, Chen, J, Li, L

J. Cell Biol. 2007
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Orthologous Events
Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Bos taurus)
Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Caenorhabditis elegans)
Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Canis familiaris)
Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Danio rerio)
Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Dictyostelium discoideum)
Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Drosophila melanogaster)
Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Gallus gallus)
Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Mus musculus)
Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Plasmodium falciparum)
Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Rattus norvegicus)
Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Saccharomyces cerevisiae)
Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Schizosaccharomyces pombe)
Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Sus scrofa)
Authored
Varusai, TM  (2019-04-04)
Reviewed
Metzakopian, E  (2019-05-24)
Created
Varusai, TM  (2019-04-04)
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