Ub:misfolded proteins polymerize to PolyUb:misfolded proteins

Stable Identifier
R-HSA-9641127
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Misfolded proteins in the cytosol are targeted to degradation via ubiquitination. The E2 UBE2N/UBE2V1 and E3 ligase ubiquitination system recruits and transfers ubiquitin molecules to misfolded proteins. The E3 ligase Parkin tags the proteins with multiple K63-linked ubiquitin molecules (Olzmann JA et al. 2007).

Literature References
PubMed ID Title Journal Year
17846173 Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6

Olzmann, JA, Li, L, Chudaev, MV, Chen, J, Perez, FA, Palmiter, RD, Chin, LS

J. Cell Biol. 2007
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