Misfolded proteins in the cytosol are targeted to degradation via ubiquitination. The E2 UBE2N/UBE2V1 and E3 ligase ubiquitination system recruits and transfers ubiquitin molecules to misfolded proteins. The E3 ligase Parkin tags the proteins with multiple K63-linked ubiquitin molecules (Olzmann JA et al. 2007).
Olzmann, JA, Li, L, Chudaev, MV, Chen, J, Perez, FA, Palmiter, RD, Chin, LS
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