Reactome | Ub:misfolded proteins polymerize to PolyUb:misfolded proteins

Schema > Polymerisation > Entries

Ub:misfolded proteins polymerize to PolyUb:misfolded proteins Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10903751
displayName	Ub:misfolded proteins polymerize to PolyUb:misfolded proteins
eventOf	[Pathway:R-DME-9646399] Aggrephagy - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-9641109] PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 - Drosophila melanogaster
inferredFrom	[Polymerisation:R-HSA-9641127] Ub:misfolded proteins polymerize to PolyUb:misfolded proteins - Homo sapiens
input	[Complex:R-DME-9641130] Ub:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Ub:misfolded proteins polymerize to PolyUb:misfolded proteins
output	[Complex:R-DME-9641113] PolyUb:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol]
precedingEvent	[Reaction:R-DME-9641111] Parkin transfers Ub to misfolded proteins - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Polymerisation
species	[Species:56210] Drosophila melanogaster
stId	R-DME-9641127
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-9646399] Aggrephagy
(precedingEvent)	[Reaction:R-DME-9641109] PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1
(inferredTo)	[Polymerisation:R-HSA-9641127] Ub:misfolded proteins polymerize to PolyUb:misfolded proteins

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