Reactome | p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol]

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p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9633011] May, Bruce, 2018-12-27
dbId	9633006
displayName	p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol]
hasComponent	[EntityWithAccessionedSequence:R-HSA-72512] EIF2S2 [cytosol] [EntityWithAccessionedSequence:R-HSA-72514] EIF2S3 [cytosol] [EntityWithAccessionedSequence:R-HSA-381060] p-S52-EIF2S1 [cytosol]
inDisease	false
inferredFrom	[Complex:R-SCE-9633544] p-S52-SUI2:SUI3:GCD11 [cytosol] - Saccharomyces cerevisiae [Complex:R-MMU-9633492] p-S52-Eif2s1:Eif2s2:Eif2s3 [cytosol] - Mus musculus
inferredTo	[Complex:R-MMU-9633006] p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] - Mus musculus [Complex:R-RNO-9633006] p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] - Rattus norvegicus [Complex:R-CFA-9633006] p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] - Canis familiaris [Complex:R-BTA-9633006] p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] - Bos taurus [Complex:R-SSC-9633006] p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] - Sus scrofa [Complex:R-DRE-9633006] p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] - Danio rerio [Complex:R-XTR-9633006] p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] - Xenopus tropicalis [Complex:R-GGA-9633006] p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] - Gallus gallus [Complex:R-DME-9633006] p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] - Drosophila melanogaster [Complex:R-CEL-9633006] p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] - Caenorhabditis elegans [Complex:R-DDI-9633006] p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] - Dictyostelium discoideum [Complex:R-SPO-9633006] p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] - Schizosaccharomyces pombe [Complex:R-SCE-9633006] p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] - Saccharomyces cerevisiae [Complex:R-PFA-9633006] p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] - Plasmodium falciparum
isChimeric	false
maxDepth	2
modified	[InstanceEdit:9648908] May, Bruce, 2019-06-10
name	p-S52-EIF2S1:EIF2S2:EIF2S3
positivelyRegulates	[PositiveRegulation:R-HSA-420845] Positive regulation by 'p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol]'
producedByEvent	[BlackBoxEvent:R-HSA-9840415] DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) - Homo sapiens [Reaction:R-HSA-9648888] p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha) - Homo sapiens [Reaction:R-HSA-9633008] p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 - Homo sapiens [Reaction:R-HSA-381111] EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK - Homo sapiens [Reaction:R-HSA-9835885] p-PKR dimer phosphorylates eIF2-alpha - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-9633006
updateTrackers	[UpdateTracker:9900827] Update Tracker - [Complex:9633006] p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] - v70:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9900827] Update Tracker - [Complex:9633006] p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] - v70:[modifyName]
(output)	[BlackBoxEvent:R-HSA-9840415] DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) [Reaction:R-HSA-9648888] p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha) [Reaction:R-HSA-9633008] p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 [Reaction:R-HSA-381111] EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK [Reaction:R-HSA-9835885] p-PKR dimer phosphorylates eIF2-alpha
(inferredTo)	[Complex:R-SCE-9633544] p-S52-SUI2:SUI3:GCD11 [cytosol] [Complex:R-MMU-9633492] p-S52-Eif2s1:Eif2s2:Eif2s3 [cytosol]
(regulator)	[PositiveRegulation:R-HSA-420845] Positive regulation by 'p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol]'

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