Reactome | GCN2 binds tRNA

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GCN2 binds tRNA Show undefined attributes

authored	[InstanceEdit:9633461] May, Bruce, 2018-12-28
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9633466] May, Bruce, 2018-12-29
dbId	9633467
displayName	GCN2 binds tRNA
edited	[InstanceEdit:9633461] May, Bruce, 2018-12-28
input	[Complex:R-SCE-9633561] GCN2:GCN1:80S ribosome:mRNA [cytosol] [GenomeEncodedEntity:R-SCE-6786699] tRNA [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9633754] Gcn1 contacts the small ribosomal protein Rps10, which is required for full activation of the protein kinase Gcn2 [LiteratureReference:9633776] The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids [LiteratureReference:9633790] Genome-wide analysis of tRNA charging and activation of the eIF2 kinase Gcn2p [LiteratureReference:9633768] Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain [LiteratureReference:9633786] The tRNA-binding moiety in GCN2 contains a dimerization domain that interacts with the kinase domain and is required for tRNA binding and kinase activation [LiteratureReference:9633730] Association of GCN1-GCN20 regulatory complex with the N-terminus of eIF2alpha kinase GCN2 is required for GCN2 activation [LiteratureReference:9633775] Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino acid-starved cells [LiteratureReference:9633729] GI domain-mediated association of the eukaryotic initiation factor 2alpha kinase GCN2 with its activator GCN1 is required for general amino acid control in budding yeast [LiteratureReference:9633860] Interaction between the tRNA-binding and C-terminal domains of Yeast Gcn2 regulates kinase activity in vivo [LiteratureReference:9633872] Enhanced interaction between pseudokinase and kinase domains in Gcn2 stimulates eIF2? phosphorylation in starved cells [LiteratureReference:9633871] Polyribosome binding by GCN1 is required for full activation of eukaryotic translation initiation factor 2{alpha} kinase GCN2 during amino acid starvation [LiteratureReference:9633779] Dimerization by translation initiation factor 2 kinase GCN2 is mediated by interactions in the C-terminal ribosome-binding region and the protein kinase domain [LiteratureReference:9633793] Dimerization is required for activation of eIF2 kinase Gcn2 in response to diverse environmental stress conditions [LiteratureReference:9633769] Conserved intermolecular salt bridge required for activation of protein kinases PKR, GCN2, and PERK [LiteratureReference:9635219] Crystal structures of GCN2 protein kinase C-terminal domains suggest regulatory differences in yeast and mammals
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GCN2 binds tRNA
orthologousEvent	[Reaction:R-MMU-9633481] Eif2ak4 binds tRNA - Mus musculus [Reaction:R-HSA-9633005] EIF2AK4 (GCN2) binds tRNA - Homo sapiens
output	[Complex:R-SCE-9633501] tRNA:GCN2:GCN1:80S ribosome:mRNA [cytosol]
releaseDate	2019-12-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9661246] Bruhat, Alain, 2019-09-15 [InstanceEdit:9668172] Staschke, Kirk A, 2019-11-20
schemaClass	Reaction
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-9633467
summation	[Summation:9633731] The histidyl-tRNA synthetase-like domain of GCN2 binds uncha...

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