Reactome | p16INK4A R112dup [cytosol]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9632568] Orlic-Milacic, Marija, 2018-12-19
crossReference	[DatabaseIdentifier:12020751] Mondo:0005105 [DatabaseIdentifier:9831455] ClinVar:VCV000183759
dbId	9632566
disease	[Disease:1500689] cancer [Disease:1614289] melanoma
displayName	p16INK4A R112dup [cytosol]
endCoordinate	156
hasModifiedResidue	[FragmentInsertionModification:9632567] Insertion of residues 112 to 112 at 113 from UniProt:P42771 CDKN2A
inDisease	true
literatureReference	[LiteratureReference:9632507] Functional evaluation of tumour-specific variants of p16INK4a/CDKN2A: correlation with protein structure information
maxDepth	1
memberOf	[CandidateSet:R-HSA-9630826] p16INK4A LoF mutants (CDK4) [cytosol] - Homo sapiens
modified	[InstanceEdit:9831457] Orlic-Milacic, Marija, 2023-03-20
name	p16INK4A R112dup p16INK4A Arg112dup CDKN2A R112dup CDKN2A Arg112dup
referenceEntity	[ReferenceGeneProduct:uniprot:P42771] UniProt:P42771 CDKN2A
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9632566
startCoordinate	1
updateTrackers	[UpdateTracker:9905718] Update Tracker - [EntityWithAccessionedSequence:9632566] p16INK4A R112dup [cytosol] - v85:[addLiteratureReference, modifyName]

(updatedInstance)	[UpdateTracker:9905718] Update Tracker - [EntityWithAccessionedSequence:9632566] p16INK4A R112dup [cytosol] - v85:[addLiteratureReference, modifyName]
(hasMember)	[CandidateSet:R-HSA-9630826] p16INK4A LoF mutants (CDK4) [cytosol]

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