Reactome | p16INK4A P81L [cytosol]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9632283] Orlic-Milacic, Marija, 2018-12-17
crossReference	[DatabaseIdentifier:12021338] Mondo:0000536 [DatabaseIdentifier:9632281] COSMIC:COSV58683884 [DatabaseIdentifier:9632286] COSMIC:COSV58718874 [DatabaseIdentifier:9632297] COSMIC:COSM1735692
dbId	9632280
disease	[Disease:1500689] cancer [Disease:1614289] melanoma [Disease:1500576] breast cancer [Disease:2327993] hepatocellular carcinoma [Disease:9630864] pancreatic ductal adenocarcinoma [Disease:2328001] skin squamous cell carcinoma [Disease:6802256] thyroid carcinoma [Disease:9630850] pharynx squamous cell carcinoma [Disease:2328083] larynx cancer [Disease:2328199] basal cell carcinoma
displayName	p16INK4A P81L [cytosol]
endCoordinate	156
hasModifiedResidue	[ReplacedResidue:9632282] L-proline 81 replaced with L-leucine
inDisease	true
literatureReference	[LiteratureReference:9631247] Functional reassessment of P16 variants using a transfection-based assay
maxDepth	1
memberOf	[CandidateSet:R-HSA-9630804] p16INK4A LoF mutants (CDK4/6) [cytosol] - Homo sapiens
modified	[InstanceEdit:9645192] Orlic-Milacic, Marija, 2019-05-06
name	p16INK4A P81L CDKN2A P81L CDKN2A Pro81Leu p16INK4A Pro81Leu
referenceEntity	[ReferenceGeneProduct:uniprot:P42771] UniProt:P42771 CDKN2A
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9632280
startCoordinate	1

(hasMember)

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