Reactome | KDM8:Fe2+ hydroxylates an arginine residue of RCCD1

Schema > Reaction > Entries

KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 Show undefined attributes

authored	[InstanceEdit:9631372] D'Eustachio, Peter, 2018-12-06
catalystActivity	[CatalystActivity:9629879] peptidyl-arginine 3-dioxygenase activity of KDM8:Fe2+ [cytosol]
catalystActivityReference	[CatalystActivityReference:9839948] peptidyl-arginine 3-dioxygenase activity of KDM8:Fe2+ [cytosol] JMJD5 is a human arginyl C-3 hydroxylase
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9629866] D'Eustachio, Peter, 2018-11-24
dbId	9629888
displayName	KDM8:Fe2+ hydroxylates an arginine residue of RCCD1
edited	[InstanceEdit:9631372] D'Eustachio, Peter, 2018-12-06
eventOf	[Pathway:R-HSA-9629569] Protein hydroxylation - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:160469] peptidyl-arginine hydroxylation
input	[SimpleEntity:R-ALL-29406] 2OG [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol] [EntityWithAccessionedSequence:R-HSA-9629873] RCCD1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9629877] Crystal structure and functional analysis of JMJD5 indicate an alternate specificity and function [LiteratureReference:9629890] Structure of the JmjC-domain-containing protein JMJD5 [LiteratureReference:9629891] JMJD5 is a human arginyl C-3 hydroxylase
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 2-oxoglutarate + L-arginyl-(protein) + O2 => (3R)-3-hydroxy-L-arginyl-(protein) + CO2 + succinate
orthologousEvent	[Reaction:R-CEL-9629888] KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 - Caenorhabditis elegans [Reaction:R-DME-9629888] KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 - Drosophila melanogaster [Reaction:R-XTR-9629888] KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 - Xenopus tropicalis [Reaction:R-SSC-9629888] KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 - Sus scrofa [Reaction:R-BTA-9629888] KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 - Bos taurus [Reaction:R-CFA-9629888] KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 - Canis familiaris [Reaction:R-RNO-9629888] KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 - Rattus norvegicus [Reaction:R-MMU-9629888] KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-9629871] 3OHR141-RCCD1 [cytosol] [SimpleEntity:R-ALL-113528] CO2 [cytosol] [SimpleEntity:R-ALL-29434] SUCCA [cytosol]
releaseDate	2023-09-13
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9629888
summation	[Summation:9629867] KDM8 (JMJC5 - JmjC domain-containing protein 5), active when...

Referrals

(hasEvent)

[Pathway:R-HSA-9629569] Protein hydroxylation

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