VGF gene expression

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Homo sapiens
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VGF is a neurosecretory protein that is expressed in neuronal cells in response to NGF signaling as well as other stimuli including cAMP (Salton et al, 1991a; Salton et al, 1991b; Hawley et al, 1992; Nagasaki et al, 1999; reviewed in Salton et al, 2000). VGF traffics through the secretory sytem where it is subject to endoproteolytic cleavage, generating small neuroactive peptides that are released upon depolarization (Possenti et al, 1989; Trani et al, 1995; Garcia et al, 2005; reviewed in Toshinai and Nakazato, 2009; Ferri et al, 2011). VGF peptides play roles in energy and water balance, depression, sensory nerves and pain perception, reproduction and neuronal apoptosis, among others (reviwed in Ferri et al, 2011). NGF-dependent expression of VGF in neuronal cells is controlled by numerous binding sites in the promixal promoter (Canu et al, 1997; Possenti et al, 1992; Di Rocco et al, 1997; D'Arcangelo et al, 1996; Mullenbrock et al, 2011). Identified DNA-binding positive regulators of NGF-dependent VGF expression include EGR1, AP-1, SP-1, CREB family members, ASCL1 and TCF12, among others (Possenti et al, 2002; Di Rocco et al, 1997; D'Arcangelo et al, 1996; Mullenbrock et al, 2011; Adams et al, 2017; Mandolesi et al, 2002).

Literature References
PubMed ID Title Journal Year
1377233 NGF induces the expression of the VGF gene through a cAMP response element

Scheibe, RJ, Hawley, RJ, Wagner, JA

J. Neurosci. 1992
28076410 Role for Egr1 in the Transcriptional Program Associated with Neuronal Differentiation of PC12 Cells

Kletsov, S, Cooper, GM, Elman, JS, Adams, KW, Lamm, RJ, Mullenbrock, S

PLoS ONE 2017
11755530 NGF-dependent and tissue-specific transcription of vgf is regulated by a CREB-p300 and bHLH factor interaction

Mandolesi, G, Gargano, S, Molfetta, R, Pennuto, M, Illi, B, Nasi, S, Levi, A, Jucker, R, Mosca, L, Soucek, L

FEBS Lett. 2002
16221685 A prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway

Ito, T, Benson, DL, Glucksman, MJ, Janssen, WG, Garcia, AL, Salton, SR, Khaing, ZZ, Han, SK

J. Biol. Chem. 2005
7595538 Tissue-specific processing of the neuroendocrine protein VGF

Ferri, GL, Levi, A, Trani, E, Possenti, R, Canu, N, Rinaldi, AM, Ciotti, T

J. Neurochem. 1995
22065583 Global expression analysis identified a preferentially nerve growth factor-induced transcriptional program regulated by sustained mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) and AP-1 protein activation during PC12 cell differentiation

Cooper, GM, Mullenbrock, S, Shah, J

J. Biol. Chem. 2011
1861162 Nucleotide sequence and regulatory studies of VGF, a nervous system-specific mRNA that is rapidly and relatively selectively induced by nerve growth factor

Salton, SR

J. Neurochem. 1991
9084409 Molecular cloning and characterization of the human VGF promoter region

Levi, A, Trani, E, Possenti, R, Canu, N, Rinaldi, AM

J. Neurochem. 1997
9032251 Interplay of the E box, the cyclic AMP response element, and HTF4/HEB in transcriptional regulation of the neurospecific, neurotrophin-inducible vgf gene

Di Rocco, G, Pennuto, M, Illi, B, Nasi, S, Trani, E, Mandolesi, G, Sirinian, MI, Levi, A, Filocamo, G, Jucker, R, Possenti, R, Canu, N, Rinaldi, AM

Mol. Cell. Biol. 1997
1570299 Regulatory elements in the promoter region of vgf, a nerve growth factor-inducible gene

Di Rocco, G, Nasi, S, Levi, A, Possenti, R

Proc. Natl. Acad. Sci. U.S.A. 1992
2017159 Structure of the gene encoding VGF, a nervous system-specific mRNA that is rapidly and selectively induced by nerve growth factor in PC12 cells

Dong, KW, Fischberg, DJ, Salton, SR

Mol. Cell. Biol. 1991
10381005 Staurosporine enhances cAMP-induced expression of neural-specific gene VGF and tyrosine hydroxylase

Sasaki, K, Maass, N, Yamaguchi, K, Hanzawa, H, Tsukada, T, Nagasaki, K

Neurosci. Lett. 1999
21621608 VGF: an inducible gene product, precursor of a diverse array of neuro-endocrine peptides and tissue-specific disease biomarkers

D'Amato, F, Cocco, C, Ferri, GL, Noli, B, Brancia, C

J. Chem. Neuroanat. 2011
19194657 Neuroendocrine regulatory peptide-1 and -2: novel bioactive peptides processed from VGF

Nakazato, M, Toshinai, K

Cell. Mol. Life Sci. 2009
2676516 A protein induced by NGF in PC12 cells is stored in secretory vesicles and released through the regulated pathway

Paterson, BM, Grasso, A, Levi, A, Eldridge, JD, Possenti, R

EMBO J. 1989
8756618 Activation of codependent transcription factors is required for transcriptional induction of the vgf gene by nerve growth factor and Ras

D'Arcangelo, G, Salton, SR, Halegoua, S, Habas, R, Wang, S

Mol. Cell. Biol. 1996
10882540 VGF: a novel role for this neuronal and neuroendocrine polypeptide in the regulation of energy balance

Wilson, AJ, Salton, SR, Ferri, GL, Levi, A, Hahm, S, Possenti, R, Snyder, SE

Front Neuroendocrinol 2000
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