Reactome | SOD2 gene expression is stimulated by FOXO4, FOXO3 and FOXO1

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SOD2 gene expression is stimulated by FOXO4, FOXO3 and FOXO1 Show undefined attributes

authored	[InstanceEdit:9624371] Orlic-Milacic, Marija, 2018-10-11
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9617834] Orlic-Milacic, Marija, 2018-08-30
dbId	9617833
displayName	SOD2 gene expression is stimulated by FOXO4, FOXO3 and FOXO1
edited	[InstanceEdit:9627016] Orlic-Milacic, Marija, 2018-10-31
eventOf	[Pathway:R-HSA-9615017] FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-8870704] SOD2 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9617920] FOXO4-dependent upregulation of superoxide dismutase-2 in response to oxidative stress is impaired in spinocerebellar ataxia type 3 [LiteratureReference:9617951] Regulation of FOXOs and p53 by SIRT1 modulators under oxidative stress [LiteratureReference:9617960] CD38 Deficiency Protects the Heart from Ischemia/Reperfusion Injury through Activating SIRT1/FOXOs-Mediated Antioxidative Stress Pathway [LiteratureReference:9617975] Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SOD2 gene expression is stimulated by FOXO4, FOXO3 and FOXO1
output	[EntityWithAccessionedSequence:R-HSA-3299687] SOD2 [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-9617832] FOXO4:ATXN3 binds SOD2 gene promoter - Homo sapiens [Reaction:R-HSA-9617972] FOXO3 binds SOD2 gene promoter - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:9617935] Positive gene expression regulation by 'FOXO4:ATXN3:SOD2 gene [nucleoplasm]' [PositiveRegulation:9617959] Positive regulation by 'FOXO1 [nucleoplasm]' [PositiveGeneExpressionRegulation:9617976] Positive gene expression regulation by 'FOXO3:SOD2 gene [nucleoplasm]'
releaseDate	2018-12-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9625979] Donlon, Timothy, 2018-10-17 [InstanceEdit:9626974] Bertaggia, Enrico, 2018-10-26
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9617833
summation	[Summation:9617831] FOXO3 directly stimulates transcription of the SOD2 gene, en...

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[Pathway:R-HSA-9615017] FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes

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